Assay Detail
Functional
CHEMBL656834
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Inhibitory activity against HIV Tat-regulated Transactivation in COS cells.
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | COS-1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Antiviral activities of methylated nordihydroguaiaretic acids. 1. Synthesis, structure identification, and inhibition of tat-regulated HIV transactivation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.69 | 4.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL90983 | TERAMEPROCOL | 2.0 | 1 | 4.96 |
| CHEMBL323350 | — | — | 1 | 4.87 |
| CHEMBL100460 | — | — | 1 | 4.84 |
| CHEMBL91531 | — | — | 1 | 4.78 |
| CHEMBL316139 | — | — | 1 | 4.60 |
| CHEMBL103600 | DIMETHYLNORDIHYDROGUARIERATE ACID | — | 1 | 4.53 |
| CHEMBL101175 | — | — | 1 | 4.51 |
| CHEMBL430464 | MESODIHYDROGUAIARETIC ACID | — | 1 | 4.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL90983 | TERAMEPROCOL | IC50 | = | 11090.0 | nM | 4.96 |
| CHEMBL323350 | — | IC50 | = | 13660.0 | nM | 4.87 |
| CHEMBL100460 | — | IC50 | = | 14310.0 | nM | 4.84 |
| CHEMBL91531 | — | IC50 | = | 16520.0 | nM | 4.78 |
| CHEMBL316139 | — | IC50 | = | 25030.0 | nM | 4.60 |
| CHEMBL103600 | DIMETHYLNORDIHYDROGUARIERATE ACID | IC50 | = | 29880.0 | nM | 4.53 |
| CHEMBL101175 | — | IC50 | = | 30810.0 | nM | 4.51 |
| CHEMBL430464 | MESODIHYDROGUAIARETIC ACID | IC50 | = | 38980.0 | nM | 4.41 |