Assay Detail
Functional
CHEMBL656841
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of Ras processing in COS cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | COS |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Inhibitors of farnesyl protein transferase. Synthesis and biological activity of amide and cyanoguanidine derivatives containing a 5,11-dihydro[1]benzthiepin, benzoxepin, and benzazepin [4,3-b]pyridine ring system.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.33 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL289404 | — | — | 1 | 6.00 |
| CHEMBL81889 | — | — | 1 | 5.77 |
| CHEMBL311310 | — | — | 1 | 5.43 |
| CHEMBL313193 | — | — | 1 | 5.42 |
| CHEMBL315067 | — | — | 1 | 5.38 |
| CHEMBL315599 | — | — | 1 | 5.30 |
| CHEMBL423677 | — | — | 1 | 5.00 |
| CHEMBL309483 | — | — | 1 | 5.00 |
| CHEMBL84036 | — | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL289404 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL81889 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL311310 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL313193 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL315067 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL315599 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL423677 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL309483 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL84036 | — | IC50 | = | 20000.0 | nM | 4.70 |