Compound Detail
CHEMBL315599
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Basic Information
| ChEMBL ID | CHEMBL315599 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HVTQOXXHYUJBJU-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
496.1
MW (Da)
5.19
ALogP
5
HBA
0
HBD
60.1
PSA (Ų)
0.28
QED
1
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.21
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein farnesyltransferase CHEMBL2094108 | IC50 | 6.21 | 5.755 | 620.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein farnesyltransferase | IC50 | = | 620.0 | nM | 6.21 | In vitro FPT potency by measuring the ability to inhibit the transfer of [3H]far... | 9873573 |
| Protein farnesyltransferase | IC50 | = | 5000.0 | nM | 5.3 | In vitro inhibition of Ras processing in COS cells | 9873573 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 9873573 | 10.1016/s0960-894x(98)00439-9 | Protein farnesyltransferase | 2 |
Data from ChEMBL 36 via Core Engine