Assay Detail
Functional
CHEMBL656866
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Concentration giving half-maximal contraction of the cat iris sphincter muscle was determined in vitro
10
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Felis catus |
| Tissue | Sphincter muscle |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Derivatives of 17-phenyl-18,19,20-trinorprostaglandin F2 alpha isopropyl ester: potential antiglaucoma agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 7.17 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL102221 | — | — | 1 | 9.15 |
| CHEMBL419907 | — | — | 1 | 8.37 |
| CHEMBL318588 | — | — | 2 | 8.31 |
| CHEMBL815 | DINOPROST | 4.0 | 1 | 8.17 |
| CHEMBL2111626 | — | — | 1 | 7.46 |
| CHEMBL102258 | — | — | 1 | 7.40 |
| CHEMBL105510 | — | — | 2 | 5.72 |
| CHEMBL2112435 | — | — | 1 | 5.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL102221 | — | EC50 | = | 0.71 | nM | 9.15 |
| CHEMBL419907 | — | EC50 | = | 4.3 | nM | 8.37 |
| CHEMBL318588 | — | EC50 | = | 4.9 | nM | 8.31 |
| CHEMBL815 | DINOPROST | EC50 | = | 6.7 | nM | 8.17 |
| CHEMBL318588 | — | EC50 | = | 33.0 | nM | 7.48 |
| CHEMBL2111626 | — | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL102258 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL105510 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL2112435 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL105510 | — | EC50 | = | 100000.0 | nM | 4.00 |