Assay Detail
Functional
CHEMBL656869
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In vitro inotropic effect in cat papillary muscle
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Felis catus |
| Tissue | Papillary muscle |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Chemistry and positive inotropic effect of pelrinone and related derivatives. A novel class of 2-methylpyrimidones as inotropic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 5.45 | 5.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL165705 | — | — | 1 | 5.60 |
| CHEMBL17125 | PELRINONE | 2.0 | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL165705 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL17125 | PELRINONE | EC50 | = | 5000.0 | nM | 5.30 |