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Assay Detail

CHEMBL657025

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Binding
Inhibitory activity against bovine lung microsomes carbonic anhydrase isozyme IV (bCA IV).
ChEMBL ↗
59
Total Activities
59
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Carbonic anhydrase 4 (CHEMBL281) ↗
Type SINGLE PROTEIN
Organism Bos taurus

Publication

Carbonic anhydrase inhibitors. Synthesis of water-soluble, topically effective, intraocular pressure-lowering aromatic/heterocyclic sulfonamides containing cationic or anionic moieties: is the tail more important than the ring?
Scozzafava A, Menabuoni L, Mincione F, Briganti F, Mincione G, Supuran CT.
J Med Chem (1999) 42 : 2641 -2650
PubMed 10411484 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 59 7.01 8.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL420610 — — 1 8.05
CHEMBL316037 — — 1 8.05
CHEMBL90382 — — 1 8.00
CHEMBL89163 — — 1 8.00
CHEMBL314929 — — 1 7.96
CHEMBL313925 — — 1 7.89
CHEMBL287117 — — 1 7.82
CHEMBL313770 — — 1 7.77
CHEMBL6685 — — 1 7.77
CHEMBL327487 — — 1 7.75
CHEMBL88232 — — 1 7.75
CHEMBL35118 — — 1 7.72
CHEMBL85120 — — 1 7.72
CHEMBL85079 — — 1 7.68
CHEMBL88860 — — 1 7.40
CHEMBL87141 — — 1 7.36
CHEMBL218490 DORZOLAMIDE 4.0 1 7.35
CHEMBL220491 BRINZOLAMIDE 4.0 1 7.34
CHEMBL88120 — — 1 7.34
CHEMBL328946 — — 1 7.32
CHEMBL88173 — — 1 7.27
CHEMBL89634 — — 1 7.26
CHEMBL88519 — — 1 7.22
CHEMBL88969 — — 1 7.21
CHEMBL6724 — — 1 7.18
CHEMBL90218 — — 1 7.18
CHEMBL315661 — — 1 7.16
CHEMBL86428 — — 1 7.16
CHEMBL432818 — — 1 7.16
CHEMBL327933 — — 1 7.16

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL420610 — Ki = 9.0 nM 8.05
CHEMBL316037 — Ki = 9.0 nM 8.05
CHEMBL89163 — Ki = 10.0 nM 8.00
CHEMBL90382 — Ki = 10.0 nM 8.00
CHEMBL314929 — Ki = 11.0 nM 7.96
CHEMBL313925 — Ki = 13.0 nM 7.89
CHEMBL287117 — Ki = 15.0 nM 7.82
CHEMBL313770 — Ki = 17.0 nM 7.77
CHEMBL6685 — Ki = 17.0 nM 7.77
CHEMBL327487 — Ki = 18.0 nM 7.75
CHEMBL88232 — Ki = 18.0 nM 7.75
CHEMBL35118 — Ki = 19.0 nM 7.72
CHEMBL85120 — Ki = 19.0 nM 7.72
CHEMBL85079 — Ki = 21.0 nM 7.68
CHEMBL88860 — Ki = 40.0 nM 7.40
CHEMBL87141 — Ki = 44.0 nM 7.36
CHEMBL218490 DORZOLAMIDE Ki = 45.0 nM 7.35
CHEMBL220491 BRINZOLAMIDE Ki = 45.3 nM 7.34
CHEMBL88120 — Ki = 46.0 nM 7.34
CHEMBL328946 — Ki = 48.0 nM 7.32
CHEMBL88173 — Ki = 54.0 nM 7.27
CHEMBL89634 — Ki = 55.0 nM 7.26
CHEMBL88519 — Ki = 60.0 nM 7.22
CHEMBL88969 — Ki = 62.0 nM 7.21
CHEMBL90218 — Ki = 66.0 nM 7.18
CHEMBL6724 — Ki = 66.0 nM 7.18
CHEMBL315661 — Ki = 70.0 nM 7.16
CHEMBL86428 — Ki = 69.0 nM 7.16
CHEMBL432818 — Ki = 69.0 nM 7.16
CHEMBL327933 — Ki = 70.0 nM 7.16
CHEMBL316140 — Ki = 75.0 nM 7.12
CHEMBL89455 — Ki = 79.0 nM 7.10
CHEMBL315592 — Ki = 79.0 nM 7.10
CHEMBL89945 — Ki = 105.0 nM 6.98
CHEMBL280071 — Ki = 120.0 nM 6.92
CHEMBL13646 — Ki = 125.0 nM 6.90
CHEMBL268177 — Ki = 125.0 nM 6.90
CHEMBL90492 — Ki = 150.0 nM 6.82
CHEMBL266240 — Ki = 160.0 nM 6.80
CHEMBL330346 — Ki = 170.0 nM 6.77
CHEMBL269628 — Ki = 175.0 nM 6.76
CHEMBL6853 — Ki = 180.0 nM 6.75
CHEMBL92116 — Ki = 285.0 nM 6.54
CHEMBL327669 — Ki = 300.0 nM 6.52
CHEMBL327604 — Ki = 304.0 nM 6.52
CHEMBL91420 — Ki = 300.0 nM 6.52
CHEMBL86751 — Ki = 305.0 nM 6.52
CHEMBL313123 — Ki = 310.0 nM 6.51
CHEMBL7092 — Ki = 320.0 nM 6.50
CHEMBL6753 — Ki = 355.0 nM 6.45