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Assay Detail

CHEMBL657028

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Binding
Inhibitory activity against bovine carbonic anhydrase IV (CA4), isolated from bovine lung microsomes
ChEMBL ↗
130
Total Activities
130
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Carbonic anhydrase 4 (CHEMBL281) ↗
Type SINGLE PROTEIN
Organism Bos taurus

Publication

Carbonic anhydrase inhibitors: synthesis of water-soluble, aminoacyl/dipeptidyl sulfonamides possessing long-lasting intraocular pressure-lowering properties via the topical route.
Scozzafava A, Briganti F, Mincione G, Menabuoni L, Mincione F, Supuran CT.
J Med Chem (1999) 42 : 3690 -3700
PubMed 10479300 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 130 7.17 9.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL331083 — — 1 9.10
CHEMBL268439 — — 1 8.30
CHEMBL419604 — — 1 8.30
CHEMBL331697 — — 1 8.22
CHEMBL331527 — — 1 8.22
CHEMBL122786 — — 1 8.22
CHEMBL123606 — — 1 8.15
CHEMBL332648 — — 1 8.10
CHEMBL332220 — — 1 8.05
CHEMBL451190 — — 1 8.05
CHEMBL123539 — — 1 8.05
CHEMBL331386 — — 1 8.00
CHEMBL333874 — — 1 8.00
CHEMBL330755 — — 1 7.96
CHEMBL332221 — — 1 7.92
CHEMBL123108 — — 1 7.92
CHEMBL332222 — — 1 7.85
CHEMBL287117 — — 1 7.82
CHEMBL122720 — — 1 7.82
CHEMBL123599 — — 1 7.82
CHEMBL6685 — — 1 7.77
CHEMBL126179 — — 1 7.75
CHEMBL35118 — — 1 7.72
CHEMBL122390 — — 1 7.64
CHEMBL2112600 — — 1 7.57
CHEMBL341002 — — 1 7.52
CHEMBL541990 — — 1 7.52
CHEMBL2112602 — — 1 7.51
CHEMBL2112599 — — 1 7.46
CHEMBL122349 — — 1 7.46

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL331083 — Ki = 0.8 nM 9.10
CHEMBL419604 — Ki = 5.0 nM 8.30
CHEMBL268439 — Ki = 5.0 nM 8.30
CHEMBL331697 — Ki = 6.0 nM 8.22
CHEMBL122786 — Ki = 6.0 nM 8.22
CHEMBL331527 — Ki = 6.0 nM 8.22
CHEMBL123606 — Ki = 7.0 nM 8.15
CHEMBL332648 — Ki = 8.0 nM 8.10
CHEMBL332220 — Ki = 9.0 nM 8.05
CHEMBL123539 — Ki = 9.0 nM 8.05
CHEMBL451190 — Ki = 9.0 nM 8.05
CHEMBL333874 — Ki = 10.0 nM 8.00
CHEMBL331386 — Ki = 10.0 nM 8.00
CHEMBL330755 — Ki = 11.0 nM 7.96
CHEMBL123108 — Ki = 12.0 nM 7.92
CHEMBL332221 — Ki = 12.0 nM 7.92
CHEMBL332222 — Ki = 14.0 nM 7.85
CHEMBL123599 — Ki = 15.0 nM 7.82
CHEMBL122720 — Ki = 15.0 nM 7.82
CHEMBL287117 — Ki = 15.0 nM 7.82
CHEMBL6685 — Ki = 17.0 nM 7.77
CHEMBL126179 — Ki = 18.0 nM 7.75
CHEMBL35118 — Ki = 19.0 nM 7.72
CHEMBL122390 — Ki = 23.0 nM 7.64
CHEMBL2112600 — Ki = 27.0 nM 7.57
CHEMBL341002 — Ki = 30.0 nM 7.52
CHEMBL541990 — Ki = 30.0 nM 7.52
CHEMBL2112602 — Ki = 31.0 nM 7.51
CHEMBL2112599 — Ki = 35.0 nM 7.46
CHEMBL122349 — Ki = 35.0 nM 7.46
CHEMBL122951 — Ki = 39.0 nM 7.41
CHEMBL331738 — Ki = 39.0 nM 7.41
CHEMBL121696 — Ki = 40.0 nM 7.40
CHEMBL333692 — Ki = 41.0 nM 7.39
CHEMBL123065 — Ki = 42.0 nM 7.38
CHEMBL122444 — Ki = 43.0 nM 7.37
CHEMBL123047 — Ki = 44.0 nM 7.36
CHEMBL332744 — Ki = 45.0 nM 7.35
CHEMBL218490 DORZOLAMIDE Ki = 45.0 nM 7.35
CHEMBL122781 — Ki = 45.0 nM 7.35
CHEMBL123878 — Ki = 46.0 nM 7.34
CHEMBL125729 — Ki = 46.0 nM 7.34
CHEMBL269122 — Ki = 50.0 nM 7.30
CHEMBL122808 — Ki = 50.0 nM 7.30
CHEMBL123398 — Ki = 51.0 nM 7.29
CHEMBL333033 — Ki = 51.0 nM 7.29
CHEMBL14182 — Ki = 53.0 nM 7.28
CHEMBL122074 — Ki = 54.0 nM 7.27
CHEMBL122756 — Ki = 55.0 nM 7.26
CHEMBL121662 — Ki = 55.0 nM 7.26