Assay Detail
Binding
CHEMBL657031
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against carbonic anhydrase IV from bovine lung microsomes
48
Total Activities
48
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Carbonic anhydrase inhibitors: the first selective, membrane-impermeant inhibitors targeting the tumor-associated isozyme IX.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 48 | 6.57 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL352483 | — | — | 1 | 7.70 |
| CHEMBL170592 | — | — | 1 | 7.68 |
| CHEMBL171589 | — | — | 1 | 7.68 |
| CHEMBL169869 | — | — | 1 | 7.50 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 7.44 |
| CHEMBL171031 | — | — | 1 | 7.29 |
| CHEMBL169684 | — | — | 1 | 7.28 |
| CHEMBL352535 | — | — | 1 | 7.22 |
| CHEMBL170875 | — | — | 1 | 7.21 |
| CHEMBL77517 | INDISULAM | 2.0 | 1 | 7.19 |
| CHEMBL169188 | — | — | 1 | 7.16 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.16 |
| CHEMBL169789 | — | — | 1 | 7.16 |
| CHEMBL366775 | — | — | 1 | 7.16 |
| CHEMBL353514 | — | — | 1 | 7.10 |
| CHEMBL168976 | — | — | 1 | 7.09 |
| CHEMBL422747 | — | — | 1 | 7.05 |
| CHEMBL170938 | — | — | 1 | 7.04 |
| CHEMBL169623 | — | — | 1 | 7.00 |
| CHEMBL354626 | — | — | 1 | 6.84 |
| CHEMBL355026 | — | — | 1 | 6.84 |
| CHEMBL355320 | — | — | 1 | 6.79 |
| CHEMBL352612 | — | — | 1 | 6.79 |
| CHEMBL422907 | — | — | 1 | 6.74 |
| CHEMBL171792 | — | — | 1 | 6.71 |
| CHEMBL171350 | — | — | 1 | 6.68 |
| CHEMBL170085 | — | — | 1 | 6.54 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 6.42 |
| CHEMBL169820 | — | — | 1 | 6.12 |
| CHEMBL170588 | — | — | 1 | 6.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL352483 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL170592 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL171589 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL169869 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL171031 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL169684 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL352535 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL170875 | — | Ki | = | 61.0 | nM | 7.21 |
| CHEMBL77517 | INDISULAM | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL366775 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL169789 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL169188 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL353514 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL168976 | — | Ki | = | 82.0 | nM | 7.09 |
| CHEMBL422747 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL170938 | — | Ki | = | 92.0 | nM | 7.04 |
| CHEMBL169623 | — | Ki | = | 101.0 | nM | 7.00 |
| CHEMBL354626 | — | Ki | = | 144.0 | nM | 6.84 |
| CHEMBL355026 | — | Ki | = | 144.0 | nM | 6.84 |
| CHEMBL355320 | — | Ki | = | 161.0 | nM | 6.79 |
| CHEMBL352612 | — | Ki | = | 163.0 | nM | 6.79 |
| CHEMBL422907 | — | Ki | = | 182.0 | nM | 6.74 |
| CHEMBL171792 | — | Ki | = | 194.0 | nM | 6.71 |
| CHEMBL171350 | — | Ki | = | 211.0 | nM | 6.68 |
| CHEMBL170085 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 380.0 | nM | 6.42 |
| CHEMBL169820 | — | Ki | = | 761.0 | nM | 6.12 |
| CHEMBL170588 | — | Ki | = | 852.0 | nM | 6.07 |
| CHEMBL352768 | — | Ki | = | 864.0 | nM | 6.06 |
| CHEMBL172567 | — | Ki | = | 983.0 | nM | 6.01 |
| CHEMBL171095 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL169903 | — | Ki | = | 1055.0 | nM | 5.98 |
| CHEMBL168383 | — | Ki | = | 1070.0 | nM | 5.97 |
| CHEMBL169617 | — | Ki | = | 1214.0 | nM | 5.92 |
| CHEMBL353693 | — | Ki | = | 1260.0 | nM | 5.90 |
| CHEMBL170151 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL171625 | — | Ki | = | 1483.0 | nM | 5.83 |
| CHEMBL354732 | — | Ki | = | 1830.0 | nM | 5.74 |
| CHEMBL354197 | — | Ki | = | 1905.0 | nM | 5.72 |
| CHEMBL168431 | — | Ki | = | 1954.0 | nM | 5.71 |
| CHEMBL355309 | — | Ki | = | 1956.0 | nM | 5.71 |
| CHEMBL366948 | — | Ki | = | 2008.0 | nM | 5.70 |
| CHEMBL170041 | — | Ki | = | 2104.0 | nM | 5.68 |
| CHEMBL170145 | — | Ki | = | 2102.0 | nM | 5.68 |
| CHEMBL446175 | — | Ki | = | 2155.0 | nM | 5.67 |
| CHEMBL171221 | — | Ki | = | 2500.0 | nM | 5.60 |