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Assay Detail

CHEMBL657032

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of bovine carbonic anhydrase IV (CA4) from bovine lung microsomes
155
Total Activities
155
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Carbonic anhydrase 4 (CHEMBL281)
Type SINGLE PROTEIN
Organism Bos taurus

Publication

Carbonic anhydrase inhibitors: perfluoroalkyl/aryl-substituted derivatives of aromatic/heterocyclic sulfonamides as topical intraocular pressure-lowering agents with prolonged duration of action.
Scozzafava A, Menabuoni L, Mincione F, Briganti F, Mincione G, Supuran CT.
J Med Chem (2000) 43 : 4542 -4551
PubMed 11087579 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 155 6.76 8.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL342026 1 8.30
CHEMBL140110 1 8.30
CHEMBL140481 1 8.22
CHEMBL142132 1 8.22
CHEMBL94836 1 8.22
CHEMBL141753 1 8.22
CHEMBL139946 1 8.15
CHEMBL140792 1 8.15
CHEMBL140370 1 8.15
CHEMBL141899 1 8.15
CHEMBL141624 1 8.15
CHEMBL342610 1 8.10
CHEMBL140805 1 8.10
CHEMBL69149 1 8.10
CHEMBL343916 1 8.10
CHEMBL141351 1 8.10
CHEMBL264879 1 8.10
CHEMBL141868 1 8.05
CHEMBL138253 1 8.05
CHEMBL138920 1 8.05
CHEMBL140095 1 8.05
CHEMBL337369 1 8.05
CHEMBL138603 1 8.05
CHEMBL141168 1 8.05
CHEMBL341760 1 8.00
CHEMBL140879 1 8.00
CHEMBL344382 1 8.00
CHEMBL344156 1 8.00
CHEMBL138812 1 7.96
CHEMBL140616 1 7.96

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL140110 Ki = 5.0 nM 8.30
CHEMBL342026 Ki = 5.0 nM 8.30
CHEMBL141753 Ki = 6.0 nM 8.22
CHEMBL142132 Ki = 6.0 nM 8.22
CHEMBL140481 Ki = 6.0 nM 8.22
CHEMBL94836 Ki = 6.0 nM 8.22
CHEMBL140370 Ki = 7.0 nM 8.15
CHEMBL141624 Ki = 7.0 nM 8.15
CHEMBL140792 Ki = 7.0 nM 8.15
CHEMBL139946 Ki = 7.0 nM 8.15
CHEMBL141899 Ki = 7.0 nM 8.15
CHEMBL342610 Ki = 8.0 nM 8.10
CHEMBL140805 Ki = 8.0 nM 8.10
CHEMBL141351 Ki = 8.0 nM 8.10
CHEMBL69149 Ki = 8.0 nM 8.10
CHEMBL343916 Ki = 8.0 nM 8.10
CHEMBL264879 Ki = 8.0 nM 8.10
CHEMBL140095 Ki = 9.0 nM 8.05
CHEMBL141168 Ki = 9.0 nM 8.05
CHEMBL141868 Ki = 9.0 nM 8.05
CHEMBL138603 Ki = 9.0 nM 8.05
CHEMBL138253 Ki = 9.0 nM 8.05
CHEMBL138920 Ki = 9.0 nM 8.05
CHEMBL337369 Ki = 9.0 nM 8.05
CHEMBL344382 Ki = 10.0 nM 8.00
CHEMBL341760 Ki = 10.0 nM 8.00
CHEMBL344156 Ki = 10.0 nM 8.00
CHEMBL140879 Ki = 10.0 nM 8.00
CHEMBL140616 Ki = 11.0 nM 7.96
CHEMBL138812 Ki = 11.0 nM 7.96
CHEMBL138847 Ki = 12.0 nM 7.92
CHEMBL140791 Ki = 12.0 nM 7.92
CHEMBL139939 Ki = 13.0 nM 7.89
CHEMBL343048 Ki = 13.0 nM 7.89
CHEMBL18 ETHOXZOLAMIDE Ki = 13.0 nM 7.89
CHEMBL141898 Ki = 14.0 nM 7.85
CHEMBL337328 Ki = 14.0 nM 7.85
CHEMBL344001 Ki = 15.0 nM 7.82
CHEMBL422825 Ki = 16.0 nM 7.80
CHEMBL344034 Ki = 17.0 nM 7.77
CHEMBL141425 Ki = 18.0 nM 7.75
CHEMBL343046 Ki = 21.0 nM 7.68
CHEMBL141130 Ki = 24.0 nM 7.62
CHEMBL343944 Ki = 24.0 nM 7.62
CHEMBL139668 Ki = 25.0 nM 7.60
CHEMBL344889 Ki = 25.0 nM 7.60
CHEMBL141756 Ki = 25.0 nM 7.60
CHEMBL343098 Ki = 26.0 nM 7.58
CHEMBL337771 Ki = 29.0 nM 7.54
CHEMBL141108 Ki = 29.0 nM 7.54