Assay Detail
Binding
CHEMBL657035
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Inhibition constant evaluated for the inhibition of bovine CA IV (Carbonic anhydrase IV)
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Carbonic anhydrase inhibitors. Design of selective, membrane-impermeant inhibitors targeting the human tumor-associated isozyme IX.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 26 | 8.14 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL77402 | — | — | 1 | 8.70 |
| CHEMBL264618 | — | — | 1 | 8.68 |
| CHEMBL75812 | — | — | 1 | 8.64 |
| CHEMBL76206 | — | — | 1 | 8.62 |
| CHEMBL307402 | — | — | 1 | 8.52 |
| CHEMBL75595 | — | — | 1 | 8.52 |
| CHEMBL307401 | — | — | 1 | 8.42 |
| CHEMBL309069 | — | — | 1 | 8.39 |
| CHEMBL263457 | — | — | 1 | 8.35 |
| CHEMBL420572 | — | — | 1 | 8.34 |
| CHEMBL307259 | — | — | 1 | 8.33 |
| CHEMBL268439 | — | — | 1 | 8.29 |
| CHEMBL77986 | — | — | 1 | 8.28 |
| CHEMBL407460 | — | — | 1 | 8.27 |
| CHEMBL309578 | — | — | 1 | 8.25 |
| CHEMBL307838 | — | — | 1 | 8.24 |
| CHEMBL308820 | — | — | 1 | 8.22 |
| CHEMBL78240 | — | — | 1 | 8.15 |
| CHEMBL76078 | — | — | 1 | 8.09 |
| CHEMBL77483 | — | — | 1 | 8.08 |
| CHEMBL73929 | — | — | 1 | 8.03 |
| CHEMBL309890 | — | — | 1 | 7.99 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 7.44 |
| CHEMBL77517 | INDISULAM | 2.0 | 1 | 7.19 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.16 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 6.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL77402 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL264618 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL75812 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL76206 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL307402 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL75595 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL307401 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL309069 | — | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL263457 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL420572 | — | Ki | = | 4.6 | nM | 8.34 |
| CHEMBL307259 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL268439 | — | Ki | = | 5.1 | nM | 8.29 |
| CHEMBL77986 | — | Ki | = | 5.2 | nM | 8.28 |
| CHEMBL407460 | — | Ki | = | 5.4 | nM | 8.27 |
| CHEMBL309578 | — | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL307838 | — | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL308820 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL78240 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL76078 | — | Ki | = | 8.1 | nM | 8.09 |
| CHEMBL77483 | — | Ki | = | 8.4 | nM | 8.08 |
| CHEMBL73929 | — | Ki | = | 9.4 | nM | 8.03 |
| CHEMBL309890 | — | Ki | = | 10.3 | nM | 7.99 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL77517 | INDISULAM | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 380.0 | nM | 6.42 |