Assay Detail
Binding
CHEMBL657057
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Binding affinity towards cannabinoid receptor using [3H]CP-55940 as radioligand in rat brain membrane
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Expert |
Publication
Synthesis and pharmacological comparison of dimethylheptyl and pentyl analogs of anandamide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 8.15 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL122884 | — | — | 1 | 8.82 |
| CHEMBL123120 | — | — | 1 | 8.77 |
| CHEMBL120889 | — | — | 1 | 8.72 |
| CHEMBL429055 | — | — | 1 | 8.59 |
| CHEMBL121384 | — | — | 1 | 8.41 |
| CHEMBL120428 | — | — | 1 | 8.30 |
| CHEMBL120526 | METHANANDAMIDE | — | 1 | 7.66 |
| CHEMBL15848 | ANANDAMIDE | — | 1 | 7.60 |
| CHEMBL75591 | — | — | 1 | 7.36 |
| CHEMBL330974 | — | — | 1 | 7.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL122884 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL123120 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL120889 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL429055 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL121384 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL120428 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL120526 | METHANANDAMIDE | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL15848 | ANANDAMIDE | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL75591 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL330974 | — | Ki | = | 57.0 | nM | 7.24 |