Assay Detail
Binding
CHEMBL657123
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In vitro inhibition of human CDK2/cyclin E.
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 2/cyclin E (CHEMBL2094126) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
1H-Pyrazolo[3,4-b]pyridine inhibitors of cyclin-dependent kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.10 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL14619 | SQ-67563 | — | 1 | 6.96 |
| CHEMBL428690 | ALVOCIDIB | 3.0 | 1 | 6.77 |
| CHEMBL279405 | — | — | 1 | 6.75 |
| CHEMBL418540 | — | — | 1 | 6.75 |
| CHEMBL277795 | — | — | 1 | 6.62 |
| CHEMBL14593 | — | — | 1 | 6.55 |
| CHEMBL14327 | — | — | 1 | 6.28 |
| CHEMBL279590 | — | — | 1 | 6.18 |
| CHEMBL14709 | — | — | 1 | 5.43 |
| CHEMBL276336 | — | — | 1 | 5.36 |
| CHEMBL278709 | — | — | 1 | 4.82 |
| CHEMBL278941 | — | — | 1 | 4.77 |
| CHEMBL277160 | — | — | 1 | - |
| CHEMBL277354 | — | — | 1 | - |
| CHEMBL14799 | — | — | 1 | - |
| CHEMBL14124 | — | — | 1 | - |
| CHEMBL14856 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL14619 | SQ-67563 | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL428690 | ALVOCIDIB | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL279405 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL418540 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL277795 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL14593 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL14327 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL279590 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL14709 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL276336 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL278709 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL278941 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL277160 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL277354 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL14799 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL14124 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL14856 | — | IC50 | > | 25000.0 | nM | - |