Assay Detail
Binding
CHEMBL657124
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Inhibition of Cyclin-dependent kinase 2-cyclin E
12
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 2/cyclin E (CHEMBL2094126) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Thio- and oxoflavopiridols, cyclin-dependent kinase 1-selective inhibitors: synthesis and biological effects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.49 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428690 | ALVOCIDIB | 3.0 | 1 | 6.77 |
| CHEMBL112582 | — | — | 1 | 5.97 |
| CHEMBL1242973 | BUTYROLACTONE I | — | 1 | 5.82 |
| CHEMBL133498 | — | — | 1 | 5.68 |
| CHEMBL334881 | — | — | 2 | 5.68 |
| CHEMBL326843 | — | — | 1 | 5.41 |
| CHEMBL112050 | — | — | 1 | 5.18 |
| CHEMBL280074 | OLOMOUCINE | — | 1 | 5.16 |
| CHEMBL132888 | — | — | 1 | 5.01 |
| CHEMBL323015 | — | — | 1 | 4.39 |
| CHEMBL130395 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428690 | ALVOCIDIB | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL112582 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL1242973 | BUTYROLACTONE I | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL133498 | — | IC50 | = | 2110.0 | nM | 5.68 |
| CHEMBL334881 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL326843 | — | IC50 | = | 3930.0 | nM | 5.41 |
| CHEMBL334881 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL112050 | — | IC50 | = | 6590.0 | nM | 5.18 |
| CHEMBL280074 | OLOMOUCINE | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL132888 | — | IC50 | = | 9690.0 | nM | 5.01 |
| CHEMBL323015 | — | IC50 | = | 40400.0 | nM | 4.39 |
| CHEMBL130395 | — | IC50 | > | 25000.0 | nM | - |