Assay Detail
Binding
CHEMBL657125
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Inhibition of Cyclin-dependent kinase 2-cyclin E
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 2/cyclin E (CHEMBL2094126) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Pyrido[2,3-d]pyrimidin-7-one inhibitors of cyclin-dependent kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.79 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL140808 | — | — | 1 | 7.70 |
| CHEMBL356603 | — | — | 1 | 7.24 |
| CHEMBL140373 | — | — | 1 | 6.95 |
| CHEMBL139653 | — | — | 1 | 6.78 |
| CHEMBL143147 | — | — | 1 | 6.57 |
| CHEMBL142648 | — | — | 1 | 6.39 |
| CHEMBL143491 | — | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL140808 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL356603 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL140373 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL139653 | — | IC50 | = | 165.0 | nM | 6.78 |
| CHEMBL143147 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL142648 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL143491 | — | IC50 | = | 1200.0 | nM | 5.92 |