Assay Detail
Binding
CHEMBL657192
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Inhibitory activity against human carbonic anhydrase II.
32
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Carbonic anhydrase inhibitors: inhibition of transmembrane, tumor-associated isozyme IX, and cytosolic isozymes I and II with aliphatic sulfamates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 32 | 6.96 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL153094 | DECYL SULFAMATE | — | 2 | 9.15 |
| CHEMBL436261 | SULFAMIC ACID PHENETHYL ESTER | — | 1 | 8.96 |
| CHEMBL154865 | — | — | 1 | 8.57 |
| CHEMBL440912 | SULFAMIC ACID BENZYL ESTER | — | 1 | 8.47 |
| CHEMBL356681 | SULFAMIC ACID UNDECYL ESTER | — | 1 | 8.33 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 8.10 |
| CHEMBL153027 | SULFAMIC ACID DODECYL ESTER | — | 1 | 8.00 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.92 |
| CHEMBL345776 | — | — | 1 | 7.89 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 7.85 |
| CHEMBL422864 | — | — | 1 | 7.64 |
| CHEMBL358643 | SULFAMIC ACID PENTYL ESTER | — | 1 | 7.24 |
| CHEMBL346866 | SULFAMIC ACID CYCLOHEXYL ESTER | — | 1 | 7.22 |
| CHEMBL150652 | SULFAMIC ACID BUTYL ESTER | — | 1 | 7.16 |
| CHEMBL152907 | SULFAMIC ACID TETRADECYL ESTER | — | 1 | 7.06 |
| CHEMBL152962 | SULFAMIC ACID HEXADECYL ESTER | — | 1 | 7.01 |
| CHEMBL450930 | SULFAMIC ACID OCTADECYL ESTER | — | 1 | 6.89 |
| CHEMBL345493 | — | — | 1 | 6.24 |
| CHEMBL348471 | SULFAMIC ACID PROPYL ESTER | — | 1 | 6.12 |
| CHEMBL153068 | — | — | 1 | 6.07 |
| CHEMBL346884 | — | — | 1 | 6.05 |
| CHEMBL357533 | — | — | 1 | 5.80 |
| CHEMBL152994 | — | — | 1 | 5.35 |
| CHEMBL149514 | SULFAMIC ACID ETHYL ESTER | — | 1 | 5.26 |
| CHEMBL152967 | — | — | 1 | 5.23 |
| CHEMBL150650 | SULFAMIC ACID METHYL ESTER | — | 1 | 5.22 |
| CHEMBL24261 | OCTYL SULFAMATE | — | 1 | 5.10 |
| CHEMBL150300 | SULFAMIC ACID CYCLOPENTYL ESTER | — | 1 | - |
| CHEMBL357535 | — | — | 1 | - |
| CHEMBL357339 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL153094 | DECYL SULFAMATE | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL436261 | SULFAMIC ACID PHENETHYL ESTER | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL154865 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL440912 | SULFAMIC ACID BENZYL ESTER | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL356681 | SULFAMIC ACID UNDECYL ESTER | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL153027 | SULFAMIC ACID DODECYL ESTER | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL345776 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL422864 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL358643 | SULFAMIC ACID PENTYL ESTER | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL346866 | SULFAMIC ACID CYCLOHEXYL ESTER | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL150652 | SULFAMIC ACID BUTYL ESTER | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL152907 | SULFAMIC ACID TETRADECYL ESTER | Ki | = | 87.0 | nM | 7.06 |
| CHEMBL152962 | SULFAMIC ACID HEXADECYL ESTER | Ki | = | 97.0 | nM | 7.01 |
| CHEMBL450930 | SULFAMIC ACID OCTADECYL ESTER | Ki | = | 129.0 | nM | 6.89 |
| CHEMBL345493 | — | Ki | = | 570.0 | nM | 6.24 |
| CHEMBL348471 | SULFAMIC ACID PROPYL ESTER | Ki | = | 750.0 | nM | 6.12 |
| CHEMBL153068 | — | Ki | = | 845.0 | nM | 6.07 |
| CHEMBL346884 | — | Ki | = | 883.0 | nM | 6.05 |
| CHEMBL357533 | — | Ki | = | 1580.0 | nM | 5.80 |
| CHEMBL152994 | — | Ki | = | 4500.0 | nM | 5.35 |
| CHEMBL149514 | SULFAMIC ACID ETHYL ESTER | Ki | = | 5500.0 | nM | 5.26 |
| CHEMBL152967 | — | Ki | = | 5900.0 | nM | 5.23 |
| CHEMBL150650 | SULFAMIC ACID METHYL ESTER | Ki | = | 6000.0 | nM | 5.22 |
| CHEMBL24261 | OCTYL SULFAMATE | Ki | = | 8000.0 | nM | 5.10 |
| CHEMBL153094 | DECYL SULFAMATE | Ki | = | 9000.0 | nM | 5.05 |
| CHEMBL150300 | SULFAMIC ACID CYCLOPENTYL ESTER | Ki | > | 10000.0 | nM | - |
| CHEMBL357535 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL357339 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL153718 | SULFAMIC ACID ISOPROPYL ESTER | Ki | > | 10000.0 | nM | - |