Assay Detail
Binding
CHEMBL657263
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Ability to inhibit cyclin-dependent kinase 2-cyclin A.
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 2/cyclin A (CHEMBL2094128) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
A catch-and-release strategy for the combinatorial synthesis of 4-acylamino-1,3-thiazoles as potential CDK5 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 4.66 | 5.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL116949 | — | — | 1 | 5.30 |
| CHEMBL333136 | — | — | 1 | 5.22 |
| CHEMBL119812 | — | — | 1 | 5.00 |
| CHEMBL327004 | — | — | 1 | 5.00 |
| CHEMBL115625 | — | — | 1 | 5.00 |
| CHEMBL119143 | — | — | 1 | 5.00 |
| CHEMBL117950 | — | — | 1 | 4.82 |
| CHEMBL334091 | — | — | 1 | 4.70 |
| CHEMBL119796 | — | — | 1 | 4.70 |
| CHEMBL115650 | — | — | 1 | 4.70 |
| CHEMBL115429 | — | — | 1 | 4.70 |
| CHEMBL115472 | — | — | 1 | 4.52 |
| CHEMBL116017 | — | — | 1 | 4.52 |
| CHEMBL116615 | — | — | 1 | 4.46 |
| CHEMBL118685 | — | — | 1 | 4.40 |
| CHEMBL116339 | — | — | 1 | 4.22 |
| CHEMBL117906 | — | — | 1 | 4.16 |
| CHEMBL117778 | — | — | 1 | 4.05 |
| CHEMBL119041 | — | — | 1 | 4.05 |
| CHEMBL119530 | — | — | 1 | - |
| CHEMBL332112 | — | — | 1 | - |
| CHEMBL117779 | — | — | 1 | - |
| CHEMBL325452 | — | — | 1 | - |
| CHEMBL117800 | — | — | 1 | - |
| CHEMBL118043 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL116949 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL333136 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL119812 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL327004 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL115625 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL119143 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL117950 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL334091 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL119796 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL115650 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL115429 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL115472 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL116017 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL116615 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL118685 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL116339 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL117906 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL117778 | — | IC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL119041 | — | IC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL119530 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL332112 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL117779 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL325452 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL117800 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL118043 | — | IC50 | > | 100000.0 | nM | - |