Assay Detail
Binding
CHEMBL657264
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Cyclin-dependent kinase 2-cyclin A
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 2/cyclin A (CHEMBL2094128) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Synthesis and in vitro characterization of 1-(4-aminofurazan-3-yl)-5-dialkylaminomethyl-1H-[1,2,3]triazole-4-carboxylic acid derivatives. A new class of selective GSK-3 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.22 | 6.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL322970 | — | — | 1 | 6.42 |
| CHEMBL325353 | — | — | 1 | 4.02 |
| CHEMBL113168 | — | — | 1 | - |
| CHEMBL326705 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL322970 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL325353 | — | IC50 | = | 96000.0 | nM | 4.02 |
| CHEMBL113168 | — | IC50 | = | 119000.0 | nM | - |
| CHEMBL326705 | — | IC50 | > | 250000.0 | nM | - |