Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL657275

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
In vitro binding affinity for human Coagulation factor X
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Coagulation factor X (CHEMBL244)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of an orally efficacious inhibitor of coagulation factor Xa which incorporates a neutral P1 ligand.
Choi-Sledeski YM, Kearney R, Poli G, Pauls H, Gardner C, Gong Y, Becker M, Davis R, Spada A, Liang G, Chu V, Brown K, Collussi D, Leadley R, Rebello S, Moxey P, Morgan S, Bentley R, Kasiewski C, Maignan S, Guilloteau JP, Mikol V.
J Med Chem (2003) 46 : 681 -684
PubMed 12593648 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 24 7.31 8.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL350666 1 8.52
CHEMBL422706 1 8.52
CHEMBL161309 1 8.40
CHEMBL350169 1 8.40
CHEMBL422365 1 8.10
CHEMBL158689 1 7.75
CHEMBL350963 1 7.64
CHEMBL161432 1 7.42
CHEMBL353793 1 7.35
CHEMBL157760 1 7.32
CHEMBL158339 1 6.89
CHEMBL161158 1 6.81
CHEMBL347406 1 6.02
CHEMBL348778 1 5.99
CHEMBL422716 1 5.92
CHEMBL351435 1 5.91
CHEMBL161614 1 -
CHEMBL351494 1 -
CHEMBL351169 1 -
CHEMBL159147 1 -
CHEMBL162357 1 -
CHEMBL161683 1 -
CHEMBL160996 1 -
CHEMBL351100 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL350666 Ki = 3.0 nM 8.52
CHEMBL422706 Ki = 3.0 nM 8.52
CHEMBL161309 Ki = 4.0 nM 8.40
CHEMBL350169 Ki = 4.0 nM 8.40
CHEMBL422365 Ki = 8.0 nM 8.10
CHEMBL158689 Ki = 18.0 nM 7.75
CHEMBL350963 Ki = 23.0 nM 7.64
CHEMBL161432 Ki = 38.0 nM 7.42
CHEMBL353793 Ki = 45.0 nM 7.35
CHEMBL157760 Ki = 48.0 nM 7.32
CHEMBL158339 Ki = 128.0 nM 6.89
CHEMBL161158 Ki = 154.0 nM 6.81
CHEMBL347406 Ki = 959.0 nM 6.02
CHEMBL348778 Ki = 1022.0 nM 5.99
CHEMBL422716 Ki = 1200.0 nM 5.92
CHEMBL351435 Ki = 1219.0 nM 5.91
CHEMBL161614 Ki > 1200.0 nM -
CHEMBL351494 Ki > 1200.0 nM -
CHEMBL351169 Ki > 1200.0 nM -
CHEMBL159147 Ki > 1200.0 nM -
CHEMBL162357 Ki > 1200.0 nM -
CHEMBL161683 Ki > 1200.0 nM -
CHEMBL160996 Ki > 1200.0 nM -
CHEMBL351100 Ki > 1200.0 nM -