Assay Detail
Binding
CHEMBL657301
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Compound was evaluated for its binding affinity against Cannabinoid receptor 2 in Guinea pig ileum (GPI) using [3H]CP-55940 ligand
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
The bioactive conformation of aminoalkylindoles at the cannabinoid CB1 and CB2 receptors: insights gained from (E)- and (Z)-naphthylidene indenes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.97 | 9.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL188 | WIN-552122 | — | 1 | 9.55 |
| CHEMBL123916 | — | — | 1 | 8.69 |
| CHEMBL127644 | — | — | 1 | 8.56 |
| CHEMBL148805 | — | — | 1 | 6.88 |
| CHEMBL149599 | — | — | 1 | 6.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL188 | WIN-552122 | Ki | = | 0.28 | nM | 9.55 |
| CHEMBL123916 | — | Ki | = | 2.05 | nM | 8.69 |
| CHEMBL127644 | — | Ki | = | 2.72 | nM | 8.56 |
| CHEMBL148805 | — | Ki | = | 132.0 | nM | 6.88 |
| CHEMBL149599 | — | Ki | = | 658.0 | nM | 6.18 |