Assay Detail
Functional
CHEMBL657302
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Effective concentration for inhibition of human Cannabinoid receptor 2-mediated adenylyl cyclase using African green monkey (COS-7) cells transfected with the cDNA of human CB2 receptor
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Cannabinol derivatives: binding to cannabinoid receptors and inhibition of adenylylcyclase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 8.38 | 10.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL432107 | — | — | 1 | 10.11 |
| CHEMBL111724 | — | — | 1 | 9.68 |
| CHEMBL109393 | — | — | 1 | 9.10 |
| CHEMBL111148 | — | — | 1 | 9.00 |
| CHEMBL113230 | — | — | 1 | 8.34 |
| CHEMBL111340 | — | — | 1 | 8.27 |
| CHEMBL111702 | — | — | 1 | 7.41 |
| CHEMBL320408 | — | — | 1 | 6.93 |
| CHEMBL74415 | CANNABINOL | 3.0 | 1 | 6.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL432107 | — | EC50 | = | 0.078 | nM | 10.11 |
| CHEMBL111724 | — | EC50 | = | 0.208 | nM | 9.68 |
| CHEMBL109393 | — | EC50 | = | 0.79 | nM | 9.10 |
| CHEMBL111148 | — | EC50 | = | 1.01 | nM | 9.00 |
| CHEMBL113230 | — | EC50 | = | 4.6 | nM | 8.34 |
| CHEMBL111340 | — | EC50 | = | 5.4 | nM | 8.27 |
| CHEMBL111702 | — | EC50 | = | 39.3 | nM | 7.41 |
| CHEMBL320408 | — | EC50 | = | 116.2 | nM | 6.93 |
| CHEMBL74415 | CANNABINOL | EC50 | = | 261.2 | nM | 6.58 |