Assay Detail
Binding
CHEMBL657311
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Inhibitory activity against caspase-7
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Discovery of novel aspartyl ketone dipeptides as potent and selective caspase-3 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.15 | 8.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL352426 | — | — | 1 | 8.08 |
| CHEMBL81038 | — | — | 1 | 7.62 |
| CHEMBL417149 | — | — | 1 | 7.06 |
| CHEMBL166754 | — | — | 1 | 6.92 |
| CHEMBL167071 | — | — | 1 | 6.89 |
| CHEMBL167882 | — | — | 1 | 6.44 |
| CHEMBL168816 | — | — | 1 | 5.85 |
| CHEMBL166992 | — | — | 1 | 5.82 |
| CHEMBL352554 | — | — | 1 | 5.77 |
| CHEMBL354612 | — | — | 1 | 5.75 |
| CHEMBL168065 | — | — | 1 | 5.64 |
| CHEMBL167670 | — | — | 1 | 5.60 |
| CHEMBL166472 | — | — | 1 | 5.57 |
| CHEMBL168847 | — | — | 1 | 5.51 |
| CHEMBL82932 | — | — | 1 | 5.51 |
| CHEMBL166513 | — | — | 1 | 5.50 |
| CHEMBL354345 | — | — | 1 | 5.08 |
| CHEMBL353919 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL352426 | — | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL81038 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL417149 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL166754 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL167071 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL167882 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL168816 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL166992 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL352554 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL354612 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL168065 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL167670 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL166472 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL168847 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL82932 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL166513 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL354345 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL353919 | — | IC50 | > | 10000.0 | nM | - |