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Compound Detail

CHEMBL167670

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COc1ccc(OC)c(CC(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)CSCc2c(F)cccc2Cl)C(C)C)c1

Basic Information

ChEMBL ID CHEMBL167670
Phase Preclinical
Structure Type MOL
InChI Key RNMMZKILPCPBLO-LVXARBLLSA-N
5
Targets
5
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

583.1
MW (Da)
3.64
ALogP
7
HBA
3
HBD
131.0
PSA (Ų)
0.29
QED
1
Ro5 Violations
15
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C27H32ClFN2O7S
MW 583.08
Aromatic Rings 2
Heavy Atoms 39
NP-Likeness -0.87

Activity Summary

IC50 5 meas. best 7.14

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Caspase-3
CHEMBL2334
IC50 7.14 7.14 73.0 1
Caspase-8
CHEMBL3776
IC50 5.62 5.62 2400.0 1
Caspase-7
CHEMBL3468
IC50 5.6 5.6 2500.0 1
Caspase-1
CHEMBL4801
IC50 5.3 5.3 5000.0 1
NT2
CHEMBL614205
IC50 5.05 5.05 9000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

Data from ChEMBL 36 via Core Engine