Assay Detail
Binding
CHEMBL659708
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Inhibitory activity against caspase-8
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Discovery of novel aspartyl ketone dipeptides as potent and selective caspase-3 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.47 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL417149 | — | — | 1 | 6.89 |
| CHEMBL166754 | — | — | 1 | 6.31 |
| CHEMBL167882 | — | — | 1 | 6.09 |
| CHEMBL352426 | — | — | 1 | 5.82 |
| CHEMBL353919 | — | — | 1 | 5.70 |
| CHEMBL82932 | — | — | 1 | 5.64 |
| CHEMBL167670 | — | — | 1 | 5.62 |
| CHEMBL167071 | — | — | 1 | 5.54 |
| CHEMBL168816 | — | — | 1 | 5.48 |
| CHEMBL81038 | — | — | 1 | 5.42 |
| CHEMBL168065 | — | — | 1 | 5.20 |
| CHEMBL166513 | — | — | 1 | 5.18 |
| CHEMBL354612 | — | — | 1 | 5.11 |
| CHEMBL166992 | — | — | 1 | 5.06 |
| CHEMBL352554 | — | — | 1 | 5.03 |
| CHEMBL168847 | — | — | 1 | 4.85 |
| CHEMBL166472 | — | — | 1 | 4.81 |
| CHEMBL354345 | — | — | 1 | 4.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL417149 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL166754 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL167882 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL352426 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL353919 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL82932 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL167670 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL167071 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL168816 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL81038 | — | IC50 | = | 3850.0 | nM | 5.42 |
| CHEMBL168065 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL166513 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL354612 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL166992 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL352554 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL168847 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL166472 | — | IC50 | = | 15500.0 | nM | 4.81 |
| CHEMBL354345 | — | IC50 | = | 22500.0 | nM | 4.65 |