Assay Detail
Binding
CHEMBL660247
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Inhibitory activity against caspase-3
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Discovery of novel aspartyl ketone dipeptides as potent and selective caspase-3 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 7.35 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL352426 | — | — | 1 | 8.74 |
| CHEMBL167882 | — | — | 1 | 8.30 |
| CHEMBL166754 | — | — | 1 | 8.30 |
| CHEMBL81038 | — | — | 1 | 8.10 |
| CHEMBL167071 | — | — | 1 | 8.00 |
| CHEMBL417149 | — | — | 1 | 7.57 |
| CHEMBL166513 | — | — | 1 | 7.32 |
| CHEMBL352554 | — | — | 1 | 7.28 |
| CHEMBL82932 | — | — | 1 | 7.22 |
| CHEMBL353919 | — | — | 1 | 7.20 |
| CHEMBL167670 | — | — | 1 | 7.14 |
| CHEMBL168816 | — | — | 1 | 7.08 |
| CHEMBL168065 | — | — | 1 | 7.03 |
| CHEMBL354612 | — | — | 1 | 6.89 |
| CHEMBL166992 | — | — | 1 | 6.85 |
| CHEMBL168847 | — | — | 1 | 6.68 |
| CHEMBL166472 | — | — | 1 | 6.51 |
| CHEMBL354345 | — | — | 1 | 6.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL352426 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL167882 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL166754 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL81038 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL167071 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL417149 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL166513 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL352554 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL82932 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL353919 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL167670 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL168816 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL168065 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL354612 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL166992 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL168847 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL166472 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL354345 | — | IC50 | = | 750.0 | nM | 6.12 |