Assay Detail
Binding
CHEMBL657358
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Inhibition of [125I]BH-CCK-8 binding to Cholecystokinin type A receptor of rat pancreatic tissue
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Cholecystokinin receptor type A (CHEMBL2871) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
CCK peptides with combined features of hexa- and tetrapeptide CCK-A agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 9.11 | 10.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3143672 | — | — | 1 | 10.70 |
| CHEMBL76248 | — | — | 1 | 10.52 |
| CHEMBL3142366 | — | — | 1 | 10.30 |
| CHEMBL1121 | SINCALIDE | 4.0 | 1 | 10.05 |
| CHEMBL323521 | — | — | 1 | 9.52 |
| CHEMBL2115177 | — | — | 1 | 9.28 |
| CHEMBL2369815 | — | — | 1 | 9.01 |
| CHEMBL3142373 | — | — | 1 | 8.47 |
| CHEMBL2369816 | — | — | 1 | 8.38 |
| CHEMBL320868 | — | — | 1 | 8.09 |
| CHEMBL2369817 | — | — | 1 | 7.72 |
| CHEMBL2369818 | — | — | 1 | 7.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3143672 | — | Ki | = | 0.02 | nM | 10.70 |
| CHEMBL76248 | — | Ki | = | 0.03 | nM | 10.52 |
| CHEMBL3142366 | — | Ki | = | 0.05 | nM | 10.30 |
| CHEMBL1121 | SINCALIDE | Ki | = | 0.09 | nM | 10.05 |
| CHEMBL323521 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL2115177 | — | Ki | = | 0.53 | nM | 9.28 |
| CHEMBL2369815 | — | Ki | = | 0.98 | nM | 9.01 |
| CHEMBL3142373 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL2369816 | — | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL320868 | — | Ki | = | 8.1 | nM | 8.09 |
| CHEMBL2369817 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL2369818 | — | Ki | = | 51.0 | nM | 7.29 |