Assay Detail
Functional
CHEMBL657424
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Activity against HIV-1 in CEM cells (in vitro)
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Aryl phosphoramidate derivatives of d4T have improved anti-HIV efficacy in tissue culture and may act by the generation of a novel intracellular metabolite.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 6.17 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.52 |
| CHEMBL45803 | — | — | 1 | 7.40 |
| CHEMBL49588 | — | — | 1 | 7.16 |
| CHEMBL295461 | — | — | 1 | 6.96 |
| CHEMBL3350117 | — | — | 1 | 6.82 |
| CHEMBL107184 | — | — | 1 | 6.74 |
| CHEMBL48644 | — | — | 1 | 6.10 |
| CHEMBL991 | STAVUDINE | 4.0 | 1 | 6.10 |
| CHEMBL48607 | — | — | 1 | 6.10 |
| CHEMBL48416 | — | — | 1 | 5.96 |
| CHEMBL49313 | — | — | 1 | 5.60 |
| CHEMBL48229 | — | — | 1 | 5.22 |
| CHEMBL300889 | — | — | 1 | 4.90 |
| CHEMBL49371 | — | — | 1 | 4.70 |
| CHEMBL49515 | — | — | 1 | 4.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL45803 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL49588 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL295461 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL3350117 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL107184 | — | EC50 | = | 182.0 | nM | 6.74 |
| CHEMBL48644 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL991 | STAVUDINE | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL48607 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL48416 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL49313 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL48229 | — | EC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL300889 | — | EC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL49371 | — | EC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL49515 | — | EC50 | = | 48000.0 | nM | 4.32 |