Assay Detail

CHEMBL657621

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Functional

In vitro inhibitory activity against growth of HIV infected CEM cell line

ChEMBL ↗

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Target

CCRF-CEM (CHEMBL382) ↗

Open DB target context

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Primary target CCRF-CEM

CHEMBL382

Anchored from Assay target.

Protein identity CCRF-CEM

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	CCRF-CEM
Confidence	1 — Organism
Curated By	Intermediate

Target

CCRF-CEM (CHEMBL382) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Synthesis and comparative evaluation of two antiviral agents: beta-L-Fd4C and beta-D-Fd4C.

Chen SH, Lin S, King I, Spinka T, Dutschman GE, Gullen EA, Cheng YC, Doyle TW.
Bioorg Med Chem Lett (1998) 8 : 3245 -3250
PubMed 9873711 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	4.60	5.19

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL38700	ELVUCITABINE	2.0	1	5.19
CHEMBL109831	DEXELVUCITABINE	2.0	1	4.00

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL38700	ELVUCITABINE	IC50	=	6500.0	nM	5.19
CHEMBL109831	DEXELVUCITABINE	IC50	=	100000.0	nM	4.00