Assay Detail
Binding
CHEMBL657649
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Inhibitory activity against low affinity binding site of Bradykinin receptor in guinea pig ileum
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Highly selective bradykinin agonists and antagonists with replacement of proline residues by N-methyl-D- and L-phenylalanine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.92 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2371649 | — | — | 1 | 9.00 |
| CHEMBL406291 | BRADYKININ | 2.0 | 1 | 8.76 |
| CHEMBL411444 | — | — | 1 | 7.60 |
| CHEMBL2371658 | — | — | 1 | 7.48 |
| CHEMBL2371657 | — | — | 1 | 6.88 |
| CHEMBL408507 | — | — | 1 | 6.16 |
| CHEMBL2371626 | — | — | 1 | 5.85 |
| CHEMBL2371654 | — | — | 1 | 5.42 |
| CHEMBL410944 | — | — | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2371649 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL406291 | BRADYKININ | IC50 | = | 1.75 | nM | 8.76 |
| CHEMBL411444 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL2371658 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL2371657 | — | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL408507 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL2371626 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL2371654 | — | IC50 | = | 3780.0 | nM | 5.42 |
| CHEMBL410944 | — | IC50 | = | 8000.0 | nM | 5.10 |