Assay Detail
Binding
CHEMBL657818
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human carbonic anhydrase I
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Carbonic anhydrase inhibitors: N-(p-sulfamoylphenyl)-alpha-D-glycopyranosylamines as topically acting antiglaucoma agents in hypertensive rabbits.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 5.95 | 6.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2112278 | — | — | 1 | 6.29 |
| CHEMBL1089967 | — | — | 1 | 6.20 |
| CHEMBL2111555 | — | — | 1 | 6.17 |
| CHEMBL2111556 | — | — | 1 | 6.12 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 6.11 |
| CHEMBL1089637 | — | — | 1 | 6.08 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 6.05 |
| CHEMBL2111554 | — | — | 1 | 6.03 |
| CHEMBL2114130 | — | — | 1 | 6.00 |
| CHEMBL2112277 | — | — | 1 | 5.92 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 5.92 |
| CHEMBL21 | SULFANILAMIDE | 4.0 | 1 | 4.55 |
| CHEMBL220491 | BRINZOLAMIDE | 4.0 | 1 | - |
| CHEMBL218490 | DORZOLAMIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2112278 | — | Ki | = | 510.0 | nM | 6.29 |
| CHEMBL1089967 | — | Ki | = | 630.0 | nM | 6.20 |
| CHEMBL2111555 | — | Ki | = | 680.0 | nM | 6.17 |
| CHEMBL2111556 | — | Ki | = | 750.0 | nM | 6.12 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 780.0 | nM | 6.11 |
| CHEMBL1089637 | — | Ki | = | 840.0 | nM | 6.08 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL2111554 | — | Ki | = | 930.0 | nM | 6.03 |
| CHEMBL2114130 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL2112277 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL21 | SULFANILAMIDE | Ki | = | 28000.0 | nM | 4.55 |
| CHEMBL220491 | BRINZOLAMIDE | Ki | - | nM | - | |
| CHEMBL218490 | DORZOLAMIDE | Ki | > | 50000.0 | nM | - |