Assay Detail
Binding
CHEMBL657820
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Inhibition constant determined against human cloned carbonic anhydrase I
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Carbonic anhydrase inhibitors. Inhibition of tumor-associated isozyme IX by halogenosulfanilamide and halogenophenylaminobenzolamide derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 43 | 6.82 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL69229 | — | — | 1 | 9.00 |
| CHEMBL304757 | — | — | 1 | 9.00 |
| CHEMBL302706 | — | — | 1 | 8.96 |
| CHEMBL305488 | — | — | 1 | 8.89 |
| CHEMBL71611 | — | — | 1 | 8.85 |
| CHEMBL306832 | — | — | 1 | 8.80 |
| CHEMBL308677 | — | — | 1 | 8.77 |
| CHEMBL70524 | — | — | 1 | 8.72 |
| CHEMBL71657 | — | — | 1 | 8.72 |
| CHEMBL68506 | — | — | 1 | 8.68 |
| CHEMBL304973 | — | — | 1 | 8.68 |
| CHEMBL307698 | — | — | 1 | 8.60 |
| CHEMBL68639 | — | — | 1 | 8.51 |
| CHEMBL22540 | — | — | 1 | 8.30 |
| CHEMBL303905 | — | — | 1 | 8.28 |
| CHEMBL23435 | — | — | 1 | 8.27 |
| CHEMBL278603 | — | — | 1 | 8.24 |
| CHEMBL268439 | — | — | 1 | 8.19 |
| CHEMBL282021 | — | — | 1 | 7.99 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 7.60 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 7.30 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 6.60 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 5.92 |
| CHEMBL441054 | — | — | 1 | 5.48 |
| CHEMBL69347 | — | — | 1 | 5.47 |
| CHEMBL69813 | — | — | 1 | 5.43 |
| CHEMBL70873 | — | — | 1 | 5.42 |
| CHEMBL303648 | — | — | 1 | 5.41 |
| CHEMBL304322 | — | — | 1 | 5.38 |
| CHEMBL268177 | — | — | 1 | 5.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL69229 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL304757 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL302706 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL305488 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL71611 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL306832 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL308677 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL70524 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL71657 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL68506 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL304973 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL307698 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL68639 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL22540 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL303905 | — | Ki | = | 5.2 | nM | 8.28 |
| CHEMBL23435 | — | Ki | = | 5.4 | nM | 8.27 |
| CHEMBL278603 | — | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL268439 | — | Ki | = | 6.4 | nM | 8.19 |
| CHEMBL282021 | — | Ki | = | 10.2 | nM | 7.99 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL441054 | — | Ki | = | 3300.0 | nM | 5.48 |
| CHEMBL69347 | — | Ki | = | 3400.0 | nM | 5.47 |
| CHEMBL69813 | — | Ki | = | 3700.0 | nM | 5.43 |
| CHEMBL70873 | — | Ki | = | 3800.0 | nM | 5.42 |
| CHEMBL303648 | — | Ki | = | 3900.0 | nM | 5.41 |
| CHEMBL304322 | — | Ki | = | 4200.0 | nM | 5.38 |
| CHEMBL268177 | — | Ki | = | 6000.0 | nM | 5.22 |
| CHEMBL308459 | — | Ki | = | 6250.0 | nM | 5.20 |
| CHEMBL6724 | — | Ki | = | 6500.0 | nM | 5.19 |
| CHEMBL70020 | — | Ki | = | 7000.0 | nM | 5.16 |
| CHEMBL430810 | — | Ki | = | 7600.0 | nM | 5.12 |
| CHEMBL68605 | — | Ki | = | 7800.0 | nM | 5.11 |
| CHEMBL6853 | — | Ki | = | 8300.0 | nM | 5.08 |
| CHEMBL265674 | — | Ki | = | 8600.0 | nM | 5.07 |
| CHEMBL7092 | — | Ki | = | 9800.0 | nM | 5.01 |
| CHEMBL306195 | — | Ki | = | 9650.0 | nM | 5.01 |
| CHEMBL430600 | — | Ki | = | 12500.0 | nM | 4.90 |
| CHEMBL67755 | — | Ki | = | 14000.0 | nM | 4.85 |
| CHEMBL21 | SULFANILAMIDE | Ki | = | 28000.0 | nM | 4.55 |
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 50000.0 | nM | 4.30 |