Assay Detail
Binding
CHEMBL657823
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Inhibition of human cloned Carbonic anhydrase I (hCA I,cytosolic form)
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Carbonic anhydrase inhibitors. Synthesis of water-soluble, topically effective, intraocular pressure-lowering aromatic/heterocyclic sulfonamides containing cationic or anionic moieties: is the tail more important than the ring?
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 6.40 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL420610 | — | — | 1 | 7.92 |
| CHEMBL90382 | — | — | 1 | 7.75 |
| CHEMBL88232 | — | — | 1 | 7.41 |
| CHEMBL6685 | — | — | 1 | 7.26 |
| CHEMBL35118 | — | — | 1 | 7.16 |
| CHEMBL13646 | — | — | 1 | 6.34 |
| CHEMBL432818 | — | — | 1 | 6.30 |
| CHEMBL88519 | — | — | 1 | 6.22 |
| CHEMBL90218 | — | — | 1 | 6.22 |
| CHEMBL330346 | — | — | 1 | 4.81 |
| CHEMBL327669 | — | — | 1 | 4.70 |
| CHEMBL86751 | — | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL420610 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL90382 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL88232 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL6685 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL35118 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL13646 | — | Ki | = | 455.0 | nM | 6.34 |
| CHEMBL432818 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL88519 | — | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL90218 | — | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL330346 | — | Ki | = | 15500.0 | nM | 4.81 |
| CHEMBL327669 | — | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL86751 | — | Ki | = | 20000.0 | nM | 4.70 |