Assay Detail
Binding
CHEMBL657824
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Inhibitory activity against human cloned carbonic anhydrase isozyme I (hCA I, cytosolic form).
46
Total Activities
46
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Carbonic anhydrase inhibitors. Synthesis of water-soluble, topically effective, intraocular pressure-lowering aromatic/heterocyclic sulfonamides containing cationic or anionic moieties: is the tail more important than the ring?
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 46 | 5.72 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL89163 | — | — | 1 | 7.82 |
| CHEMBL313925 | — | — | 1 | 7.80 |
| CHEMBL314929 | — | — | 1 | 7.75 |
| CHEMBL316037 | — | — | 1 | 7.72 |
| CHEMBL85120 | — | — | 1 | 7.46 |
| CHEMBL85079 | — | — | 1 | 7.44 |
| CHEMBL287117 | — | — | 1 | 7.30 |
| CHEMBL328946 | — | — | 1 | 6.43 |
| CHEMBL313770 | — | — | 1 | 6.40 |
| CHEMBL89634 | — | — | 1 | 6.35 |
| CHEMBL327487 | — | — | 1 | 6.35 |
| CHEMBL87141 | — | — | 1 | 6.29 |
| CHEMBL88120 | — | — | 1 | 6.27 |
| CHEMBL88860 | — | — | 1 | 6.26 |
| CHEMBL86428 | — | — | 1 | 6.24 |
| CHEMBL88969 | — | — | 1 | 6.22 |
| CHEMBL316140 | — | — | 1 | 6.22 |
| CHEMBL327933 | — | — | 1 | 6.21 |
| CHEMBL315592 | — | — | 1 | 6.21 |
| CHEMBL315661 | — | — | 1 | 6.07 |
| CHEMBL88173 | — | — | 1 | 6.07 |
| CHEMBL89455 | — | — | 1 | 5.98 |
| CHEMBL89945 | — | — | 1 | 5.70 |
| CHEMBL280071 | — | — | 1 | 5.69 |
| CHEMBL268177 | — | — | 1 | 5.22 |
| CHEMBL269628 | — | — | 1 | 5.21 |
| CHEMBL6724 | — | — | 1 | 5.19 |
| CHEMBL266240 | — | — | 1 | 5.08 |
| CHEMBL6853 | — | — | 1 | 5.08 |
| CHEMBL265674 | — | — | 1 | 5.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL89163 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL313925 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL314929 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL316037 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL85120 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL85079 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL287117 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL328946 | — | Ki | = | 370.0 | nM | 6.43 |
| CHEMBL313770 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL89634 | — | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL327487 | — | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL87141 | — | Ki | = | 510.0 | nM | 6.29 |
| CHEMBL88120 | — | Ki | = | 540.0 | nM | 6.27 |
| CHEMBL88860 | — | Ki | = | 550.0 | nM | 6.26 |
| CHEMBL86428 | — | Ki | = | 575.0 | nM | 6.24 |
| CHEMBL88969 | — | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL316140 | — | Ki | = | 605.0 | nM | 6.22 |
| CHEMBL327933 | — | Ki | = | 610.0 | nM | 6.21 |
| CHEMBL315592 | — | Ki | = | 620.0 | nM | 6.21 |
| CHEMBL315661 | — | Ki | = | 860.0 | nM | 6.07 |
| CHEMBL88173 | — | Ki | = | 845.0 | nM | 6.07 |
| CHEMBL89455 | — | Ki | = | 1040.0 | nM | 5.98 |
| CHEMBL89945 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL280071 | — | Ki | = | 2050.0 | nM | 5.69 |
| CHEMBL268177 | — | Ki | = | 6000.0 | nM | 5.22 |
| CHEMBL269628 | — | Ki | = | 6100.0 | nM | 5.21 |
| CHEMBL6724 | — | Ki | = | 6500.0 | nM | 5.19 |
| CHEMBL266240 | — | Ki | = | 8400.0 | nM | 5.08 |
| CHEMBL6853 | — | Ki | = | 8300.0 | nM | 5.08 |
| CHEMBL265674 | — | Ki | = | 8600.0 | nM | 5.07 |
| CHEMBL6753 | — | Ki | = | 9300.0 | nM | 5.03 |
| CHEMBL7092 | — | Ki | = | 9800.0 | nM | 5.01 |
| CHEMBL90492 | — | Ki | = | 15000.0 | nM | 4.82 |
| CHEMBL6784 | — | Ki | = | 18000.0 | nM | 4.75 |
| CHEMBL92116 | — | Ki | = | 18500.0 | nM | 4.73 |
| CHEMBL327604 | — | Ki | = | 20600.0 | nM | 4.69 |
| CHEMBL313123 | — | Ki | = | 21000.0 | nM | 4.68 |
| CHEMBL7087 | — | Ki | = | 21000.0 | nM | 4.68 |
| CHEMBL91420 | — | Ki | = | 21500.0 | nM | 4.67 |
| CHEMBL6919 | — | Ki | = | 24000.0 | nM | 4.62 |
| CHEMBL6852 | — | Ki | = | 25000.0 | nM | 4.60 |
| CHEMBL419 | MAFENIDE | Ki | = | 25000.0 | nM | 4.60 |
| CHEMBL21 | SULFANILAMIDE | Ki | = | 28000.0 | nM | 4.55 |
| CHEMBL6705 | — | Ki | = | 45400.0 | nM | 4.34 |
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 50000.0 | nM | 4.30 |
| CHEMBL7204 | — | Ki | = | 78500.0 | nM | 4.11 |