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Assay Detail

CHEMBL657826

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Binding
Inhibitory activity against human isoenzyme Carbonic anhydrase I
ChEMBL ↗
64
Total Activities
64
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Carbonic anhydrase 1 (CHEMBL261) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Carbonic anhydrase and matrix metalloproteinase inhibitors: sulfonylated amino acid hydroxamates with MMP inhibitory properties act as efficient inhibitors of CA isozymes I, II, and IV, and N-hydroxysulfonamides inhibit both these zinc enzymes.
Scozzafava A, Supuran CT.
J Med Chem (2000) 43 : 3677 -3687
PubMed 11020282 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 64 5.97 8.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL123167 — — 1 8.15
CHEMBL331669 — — 1 8.15
CHEMBL332406 — — 1 8.10
CHEMBL120049 — — 1 8.00
CHEMBL332858 — — 1 7.75
CHEMBL332429 — — 1 7.68
CHEMBL333248 — — 1 7.54
CHEMBL83508 — — 1 7.52
CHEMBL333896 — — 1 7.50
CHEMBL121916 — — 1 7.48
CHEMBL123443 — — 1 7.44
CHEMBL123382 — — 1 7.30
CHEMBL123463 — — 1 7.08
CHEMBL332755 — — 1 7.06
CHEMBL262676 — — 1 7.05
CHEMBL340461 — — 1 7.00
CHEMBL441084 — — 1 6.98
CHEMBL123041 — — 1 6.92
CHEMBL122711 — — 1 6.90
CHEMBL330857 — — 1 6.85
CHEMBL293503 — — 1 6.82
CHEMBL331311 — — 1 6.75
CHEMBL316169 — — 1 6.71
CHEMBL122109 — — 1 5.80
CHEMBL332439 — — 1 5.75
CHEMBL330950 — — 1 4.92
CHEMBL120934 — — 1 4.82
CHEMBL332145 — — 1 4.82
CHEMBL121501 — — 1 4.82
CHEMBL121592 — — 1 4.77

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL123167 — Ki = 7.0 nM 8.15
CHEMBL331669 — Ki = 7.0 nM 8.15
CHEMBL332406 — Ki = 8.0 nM 8.10
CHEMBL120049 — Ki = 10.0 nM 8.00
CHEMBL332858 — Ki = 18.0 nM 7.75
CHEMBL332429 — Ki = 21.0 nM 7.68
CHEMBL333248 — Ki = 29.0 nM 7.54
CHEMBL83508 — Ki = 30.0 nM 7.52
CHEMBL333896 — Ki = 32.0 nM 7.50
CHEMBL121916 — Ki = 33.0 nM 7.48
CHEMBL123443 — Ki = 36.0 nM 7.44
CHEMBL123382 — Ki = 50.0 nM 7.30
CHEMBL123463 — Ki = 84.0 nM 7.08
CHEMBL332755 — Ki = 88.0 nM 7.06
CHEMBL262676 — Ki = 90.0 nM 7.05
CHEMBL340461 — Ki = 100.0 nM 7.00
CHEMBL441084 — Ki = 105.0 nM 6.98
CHEMBL123041 — Ki = 121.0 nM 6.92
CHEMBL122711 — Ki = 127.0 nM 6.90
CHEMBL330857 — Ki = 140.0 nM 6.85
CHEMBL293503 — Ki = 150.0 nM 6.82
CHEMBL331311 — Ki = 180.0 nM 6.75
CHEMBL316169 — Ki = 195.0 nM 6.71
CHEMBL122109 — Ki = 1600.0 nM 5.80
CHEMBL332439 — Ki = 1800.0 nM 5.75
CHEMBL330950 — Ki = 12000.0 nM 4.92
CHEMBL332145 — Ki = 15000.0 nM 4.82
CHEMBL121501 — Ki = 15000.0 nM 4.82
CHEMBL120934 — Ki = 15000.0 nM 4.82
CHEMBL121592 — Ki = 17000.0 nM 4.77
CHEMBL331114 — Ki = 17000.0 nM 4.77
CHEMBL55310 — Ki = 18000.0 nM 4.75
CHEMBL333122 — Ki = 19000.0 nM 4.72
CHEMBL331308 — Ki = 20000.0 nM 4.70
CHEMBL124237 — Ki = 23000.0 nM 4.64
CHEMBL333532 — Ki = 25000.0 nM 4.60
CHEMBL301469 — Ki = 27000.0 nM 4.57
CHEMBL122925 — Ki = 30000.0 nM 4.52
CHEMBL332362 — Ki = 33000.0 nM 4.48
CHEMBL123404 — Ki = 38000.0 nM 4.42
CHEMBL123233 — Ki = 40000.0 nM 4.40
CHEMBL122950 — Ki = 41000.0 nM 4.39
CHEMBL121559 — Ki = 51000.0 nM 4.29
CHEMBL121729 — Ki = 57000.0 nM 4.24
CHEMBL123105 — Ki = 62000.0 nM 4.21
CHEMBL122868 — Ki = 68000.0 nM 4.17
CHEMBL123064 — Ki = 72000.0 nM 4.14
CHEMBL450327 — Ki > 200.0 nM -
CHEMBL440714 — Ki > 200.0 nM -
CHEMBL122831 — Ki > 200.0 nM -