Assay Detail
Binding
CHEMBL657828
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Inhibitory activity against human recombinant carbonic anhydrase I (CA1)
131
Total Activities
131
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Carbonic anhydrase inhibitors: synthesis of water-soluble, aminoacyl/dipeptidyl sulfonamides possessing long-lasting intraocular pressure-lowering properties via the topical route.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 131 | 6.37 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL331083 | — | — | 1 | 9.00 |
| CHEMBL220491 | BRINZOLAMIDE | 4.0 | 1 | 8.49 |
| CHEMBL268439 | — | — | 1 | 8.22 |
| CHEMBL330755 | — | — | 1 | 8.05 |
| CHEMBL126179 | — | — | 1 | 8.05 |
| CHEMBL122390 | — | — | 1 | 8.05 |
| CHEMBL123108 | — | — | 1 | 8.00 |
| CHEMBL332222 | — | — | 1 | 8.00 |
| CHEMBL123599 | — | — | 1 | 8.00 |
| CHEMBL123606 | — | — | 1 | 7.96 |
| CHEMBL331697 | — | — | 1 | 7.96 |
| CHEMBL541990 | — | — | 1 | 7.96 |
| CHEMBL122720 | — | — | 1 | 7.96 |
| CHEMBL122786 | — | — | 1 | 7.92 |
| CHEMBL419604 | — | — | 1 | 7.92 |
| CHEMBL125338 | — | — | 1 | 7.92 |
| CHEMBL332220 | — | — | 1 | 7.89 |
| CHEMBL331527 | — | — | 1 | 7.89 |
| CHEMBL451190 | — | — | 1 | 7.85 |
| CHEMBL333874 | — | — | 1 | 7.82 |
| CHEMBL121393 | — | — | 1 | 7.80 |
| CHEMBL340503 | — | — | 1 | 7.80 |
| CHEMBL340569 | — | — | 1 | 7.77 |
| CHEMBL332221 | — | — | 1 | 7.68 |
| CHEMBL331386 | — | — | 1 | 7.68 |
| CHEMBL332648 | — | — | 1 | 7.68 |
| CHEMBL123539 | — | — | 1 | 7.68 |
| CHEMBL269122 | — | — | 1 | 7.38 |
| CHEMBL14182 | — | — | 1 | 7.36 |
| CHEMBL123482 | — | — | 1 | 7.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL331083 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL220491 | BRINZOLAMIDE | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL268439 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL330755 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL122390 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL126179 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL123108 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL332222 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL123599 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL122720 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL541990 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL331697 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL123606 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL122786 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL419604 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL125338 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL331527 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL332220 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL451190 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL333874 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL340503 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL121393 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL340569 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL331386 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL332221 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL123539 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL332648 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL269122 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL14182 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL123482 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL123398 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL122926 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL287117 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL121782 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL121696 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL123827 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL6685 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL122795 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL121809 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL338513 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL331727 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL331331 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL122176 | — | Ki | = | 61.0 | nM | 7.21 |
| CHEMBL35118 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL2112600 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL341002 | — | Ki | = | 78.0 | nM | 7.11 |
| CHEMBL2112602 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL2112599 | — | Ki | = | 98.0 | nM | 7.01 |
| CHEMBL122349 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL333692 | — | Ki | = | 190.0 | nM | 6.72 |