Assay Detail
Binding
CHEMBL657830
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Inhibitory activity against human carbonic anhydrase I
48
Total Activities
48
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Carbonic anhydrase inhibitors: the first selective, membrane-impermeant inhibitors targeting the tumor-associated isozyme IX.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 48 | 5.28 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL77517 | INDISULAM | 2.0 | 1 | 7.52 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 7.30 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 6.60 |
| CHEMBL352483 | — | — | 1 | 6.00 |
| CHEMBL171589 | — | — | 1 | 6.00 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 5.92 |
| CHEMBL170592 | — | — | 1 | 5.70 |
| CHEMBL169684 | — | — | 1 | 5.70 |
| CHEMBL169869 | — | — | 1 | 5.70 |
| CHEMBL169789 | — | — | 1 | 5.52 |
| CHEMBL171031 | — | — | 1 | 5.52 |
| CHEMBL352535 | — | — | 1 | 5.40 |
| CHEMBL169188 | — | — | 1 | 5.40 |
| CHEMBL422747 | — | — | 1 | 5.30 |
| CHEMBL170875 | — | — | 1 | 5.30 |
| CHEMBL353514 | — | — | 1 | 5.22 |
| CHEMBL366775 | — | — | 1 | 5.22 |
| CHEMBL422907 | — | — | 1 | 5.22 |
| CHEMBL168976 | — | — | 1 | 5.16 |
| CHEMBL170938 | — | — | 1 | 5.16 |
| CHEMBL171350 | — | — | 1 | 5.16 |
| CHEMBL170085 | — | — | 1 | 5.00 |
| CHEMBL171792 | — | — | 1 | 5.00 |
| CHEMBL354626 | — | — | 1 | 4.96 |
| CHEMBL169623 | — | — | 1 | 4.92 |
| CHEMBL355026 | — | — | 1 | 4.75 |
| CHEMBL352612 | — | — | 1 | 4.62 |
| CHEMBL355320 | — | — | 1 | 4.50 |
| CHEMBL169820 | — | — | 1 | 4.40 |
| CHEMBL170588 | — | — | 1 | 4.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL77517 | INDISULAM | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL352483 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL171589 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL169869 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL169684 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL170592 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL169789 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL171031 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL352535 | — | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL169188 | — | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL422747 | — | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL170875 | — | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL353514 | — | Ki | = | 6000.0 | nM | 5.22 |
| CHEMBL422907 | — | Ki | = | 6000.0 | nM | 5.22 |
| CHEMBL366775 | — | Ki | = | 6000.0 | nM | 5.22 |
| CHEMBL168976 | — | Ki | = | 7000.0 | nM | 5.16 |
| CHEMBL170938 | — | Ki | = | 7000.0 | nM | 5.16 |
| CHEMBL171350 | — | Ki | = | 7000.0 | nM | 5.16 |
| CHEMBL170085 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL171792 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL354626 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL169623 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL355026 | — | Ki | = | 18000.0 | nM | 4.75 |
| CHEMBL352612 | — | Ki | = | 24000.0 | nM | 4.62 |
| CHEMBL355320 | — | Ki | = | 32000.0 | nM | 4.50 |
| CHEMBL169820 | — | Ki | = | 40000.0 | nM | 4.40 |
| CHEMBL170588 | — | Ki | = | 40000.0 | nM | 4.40 |
| CHEMBL172567 | — | Ki | = | 42000.0 | nM | 4.38 |
| CHEMBL170151 | — | Ki | = | 43000.0 | nM | 4.37 |
| CHEMBL171095 | — | Ki | = | 92000.0 | nM | 4.04 |
| CHEMBL352768 | — | Ki | = | 94000.0 | nM | 4.03 |
| CHEMBL170041 | — | Ki | = | 300000.0 | nM | - |
| CHEMBL353693 | — | Ki | = | 130000.0 | nM | - |
| CHEMBL171625 | — | Ki | = | 140000.0 | nM | - |
| CHEMBL169617 | — | Ki | = | 112000.0 | nM | - |
| CHEMBL366948 | — | Ki | = | 290000.0 | nM | - |
| CHEMBL355309 | — | Ki | = | 280000.0 | nM | - |
| CHEMBL170145 | — | Ki | = | 125000.0 | nM | - |
| CHEMBL168431 | — | Ki | = | 280000.0 | nM | - |
| CHEMBL446175 | — | Ki | = | 305000.0 | nM | - |
| CHEMBL354732 | — | Ki | = | 270000.0 | nM | - |
| CHEMBL171221 | — | Ki | = | 290000.0 | nM | - |
| CHEMBL168383 | — | Ki | = | 110000.0 | nM | - |
| CHEMBL169903 | — | Ki | = | 112000.0 | nM | - |
| CHEMBL354197 | — | Ki | = | 265000.0 | nM | - |