Assay Detail
Binding
CHEMBL657915
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Compound was tested for inhibition of human carbonic anhydrase (hCA II)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Docking studies of sulphamate inhibitors of estrone sulphatase in human carbonic anhydrase II.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.58 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL122708 | EMATE | — | 1 | 8.05 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.86 |
| CHEMBL167368 | — | — | 1 | 7.82 |
| CHEMBL286738 | IROSUSTAT | 2.0 | 1 | 7.77 |
| CHEMBL417656 | — | — | 1 | 7.44 |
| CHEMBL425287 | — | — | 1 | 6.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL122708 | EMATE | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL20 | ACETAZOLAMIDE | IC50 | = | 13.7 | nM | 7.86 |
| CHEMBL167368 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL286738 | IROSUSTAT | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL417656 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL425287 | — | IC50 | = | 290.0 | nM | 6.54 |