Assay Detail
Binding
CHEMBL657971
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against human carbonic anhydrase IX.
32
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Carbonic anhydrase inhibitors: inhibition of transmembrane, tumor-associated isozyme IX, and cytosolic isozymes I and II with aliphatic sulfamates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 32 | 7.25 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL153027 | SULFAMIC ACID DODECYL ESTER | — | 1 | 8.05 |
| CHEMBL436261 | SULFAMIC ACID PHENETHYL ESTER | — | 1 | 7.92 |
| CHEMBL154865 | — | — | 1 | 7.89 |
| CHEMBL440912 | SULFAMIC ACID BENZYL ESTER | — | 1 | 7.85 |
| CHEMBL152907 | SULFAMIC ACID TETRADECYL ESTER | — | 1 | 7.82 |
| CHEMBL356681 | SULFAMIC ACID UNDECYL ESTER | — | 1 | 7.77 |
| CHEMBL152962 | SULFAMIC ACID HEXADECYL ESTER | — | 1 | 7.66 |
| CHEMBL153094 | DECYL SULFAMATE | — | 2 | 7.64 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.60 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 7.57 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 7.47 |
| CHEMBL345776 | — | — | 1 | 7.19 |
| CHEMBL422864 | — | — | 1 | 7.12 |
| CHEMBL450930 | SULFAMIC ACID OCTADECYL ESTER | — | 1 | 6.92 |
| CHEMBL358643 | SULFAMIC ACID PENTYL ESTER | — | 1 | 6.90 |
| CHEMBL357533 | — | — | 1 | 6.55 |
| CHEMBL24261 | OCTYL SULFAMATE | — | 1 | 6.47 |
| CHEMBL346884 | — | — | 1 | 6.41 |
| CHEMBL153068 | — | — | 1 | 6.34 |
| CHEMBL152967 | — | — | 1 | 6.20 |
| CHEMBL150300 | SULFAMIC ACID CYCLOPENTYL ESTER | — | 1 | - |
| CHEMBL357535 | — | — | 1 | - |
| CHEMBL348471 | SULFAMIC ACID PROPYL ESTER | — | 1 | - |
| CHEMBL149514 | SULFAMIC ACID ETHYL ESTER | — | 1 | - |
| CHEMBL346866 | SULFAMIC ACID CYCLOHEXYL ESTER | — | 1 | - |
| CHEMBL152994 | — | — | 1 | - |
| CHEMBL153718 | SULFAMIC ACID ISOPROPYL ESTER | — | 1 | - |
| CHEMBL345493 | — | — | 1 | - |
| CHEMBL357339 | — | — | 1 | - |
| CHEMBL150652 | SULFAMIC ACID BUTYL ESTER | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL153027 | SULFAMIC ACID DODECYL ESTER | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL436261 | SULFAMIC ACID PHENETHYL ESTER | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL154865 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL440912 | SULFAMIC ACID BENZYL ESTER | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL152907 | SULFAMIC ACID TETRADECYL ESTER | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL356681 | SULFAMIC ACID UNDECYL ESTER | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL152962 | SULFAMIC ACID HEXADECYL ESTER | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL153094 | DECYL SULFAMATE | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL345776 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL422864 | — | Ki | = | 76.0 | nM | 7.12 |
| CHEMBL450930 | SULFAMIC ACID OCTADECYL ESTER | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL358643 | SULFAMIC ACID PENTYL ESTER | Ki | = | 126.0 | nM | 6.90 |
| CHEMBL153094 | DECYL SULFAMATE | Ki | = | 142.0 | nM | 6.85 |
| CHEMBL357533 | — | Ki | = | 279.0 | nM | 6.55 |
| CHEMBL24261 | OCTYL SULFAMATE | Ki | = | 335.0 | nM | 6.47 |
| CHEMBL346884 | — | Ki | = | 386.0 | nM | 6.41 |
| CHEMBL153068 | — | Ki | = | 458.0 | nM | 6.34 |
| CHEMBL152967 | — | Ki | = | 633.0 | nM | 6.20 |
| CHEMBL150300 | SULFAMIC ACID CYCLOPENTYL ESTER | Ki | > | 1000.0 | nM | - |
| CHEMBL357535 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL348471 | SULFAMIC ACID PROPYL ESTER | Ki | > | 1000.0 | nM | - |
| CHEMBL149514 | SULFAMIC ACID ETHYL ESTER | Ki | > | 1000.0 | nM | - |
| CHEMBL346866 | SULFAMIC ACID CYCLOHEXYL ESTER | Ki | > | 1000.0 | nM | - |
| CHEMBL152994 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL153718 | SULFAMIC ACID ISOPROPYL ESTER | Ki | > | 1000.0 | nM | - |
| CHEMBL345493 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL357339 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL150652 | SULFAMIC ACID BUTYL ESTER | Ki | > | 1000.0 | nM | - |
| CHEMBL150650 | SULFAMIC ACID METHYL ESTER | Ki | > | 1000.0 | nM | - |