Assay Detail
Binding
CHEMBL657976
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Inhibitory activity against murine carbonic anhydrase XIII (mCA XIII) by using CO2 hydrase assay method
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Carbonic anhydrase inhibitors. Inhibition of cytosolic isozyme XIII with aromatic and heterocyclic sulfonamides: a novel target for the drug design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 7.70 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7146 | — | — | 1 | 8.89 |
| CHEMBL266026 | — | — | 1 | 8.72 |
| CHEMBL268439 | — | — | 1 | 8.70 |
| CHEMBL269122 | — | — | 1 | 8.62 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.77 |
| CHEMBL218490 | DORZOLAMIDE | 4.0 | 1 | 7.75 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 7.72 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 7.64 |
| CHEMBL21 | SULFANILAMIDE | 4.0 | 1 | 7.50 |
| CHEMBL419 | MAFENIDE | 4.0 | 1 | 7.39 |
| CHEMBL6705 | — | — | 1 | 7.37 |
| CHEMBL7087 | — | — | 1 | 7.37 |
| CHEMBL6853 | — | — | 1 | 7.30 |
| CHEMBL268177 | — | — | 1 | 7.30 |
| CHEMBL6724 | — | — | 1 | 7.27 |
| CHEMBL7092 | — | — | 1 | 7.25 |
| CHEMBL865 | VALDECOXIB | 4.0 | 1 | 6.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7146 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL266026 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL268439 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL269122 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL21 | SULFANILAMIDE | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL419 | MAFENIDE | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL6705 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL7087 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL6853 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL268177 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL6724 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL7092 | — | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL865 | VALDECOXIB | Ki | = | 425.0 | nM | 6.37 |