Assay Detail
Binding
CHEMBL657999
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Inhibitory activity against DNA gyrase enzyme was determined by supercoiling assay with Escherichia coli DNA gyrase
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Structure-activity relationship in the oxazolidinone-quinolone hybrid series: influence of the central spacer on the antibacterial activity and the mode of action.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.12 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8 | CIPROFLOXACIN | 4.0 | 1 | 6.30 |
| CHEMBL134293 | — | — | 1 | 5.70 |
| CHEMBL336059 | — | — | 1 | 5.00 |
| CHEMBL131858 | — | — | 1 | 4.30 |
| CHEMBL335513 | — | — | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8 | CIPROFLOXACIN | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL134293 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL336059 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL131858 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL335513 | — | IC50 | = | 50000.0 | nM | 4.30 |