Assay Detail
Binding
CHEMBL658026
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Cyclin-dependent kinase 2-cyclin A
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 2/cyclin A (CHEMBL2094128) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Pyrido[2,3-d]pyrimidin-7-one inhibitors of cyclin-dependent kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.14 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL140808 | — | — | 1 | 7.82 |
| CHEMBL356603 | — | — | 1 | 7.43 |
| CHEMBL140373 | — | — | 1 | 7.30 |
| CHEMBL143147 | — | — | 1 | 7.24 |
| CHEMBL142648 | — | — | 1 | 6.89 |
| CHEMBL139653 | — | — | 1 | 6.68 |
| CHEMBL143491 | — | — | 1 | 6.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL140808 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL356603 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL140373 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL143147 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL142648 | — | IC50 | = | 129.0 | nM | 6.89 |
| CHEMBL139653 | — | IC50 | = | 209.0 | nM | 6.68 |
| CHEMBL143491 | — | IC50 | = | 238.0 | nM | 6.62 |