Assay Detail
Binding
CHEMBL658102
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Compound was evaluated for the inhibition of cellular DNA polymerase (gamma)
9
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Newly synthesized L-enantiomers of 3'-fluoro-modified beta-2'-deoxyribonucleoside 5'-triphosphates inhibit hepatitis B DNA polymerases but not the five cellular DNA polymerases alpha, beta, gamma, delta, and epsilon nor HIV-1 reverse transcriptase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.48 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL483492 | — | — | 2 | 6.30 |
| CHEMBL2092833 | — | — | 2 | 5.82 |
| CHEMBL2092835 | — | — | 2 | 5.70 |
| CHEMBL2092834 | — | — | 2 | 5.46 |
| CHEMBL220940 | THYMIDINE_TRIPHOSPHATE | — | 1 | 4.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL483492 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL2092833 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL2092835 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL2092834 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL220940 | THYMIDINE_TRIPHOSPHATE | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL2092835 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL483492 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2092833 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2092834 | — | IC50 | > | 100000.0 | nM | - |