Assay Detail
Binding
CHEMBL658114
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Binding affinity towards Cannabinoid receptor 1 was determined using [3H]-CP- cannabinoid as radioligand with mouse brain membrane
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Arachidonylsulfonyl derivatives as cannabinoid CB1 receptor and fatty acid amide hydrolase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.92 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL333149 | ISOPROPYL DODECYLFLUOROPHOSPHONATE | — | 1 | 8.74 |
| CHEMBL97038 | DODECANESULFONYL FLUORIDE | — | 1 | 8.16 |
| CHEMBL112486 | — | — | 1 | 6.52 |
| CHEMBL113262 | METHOXYARACHIDONOYL FLUOROPHOSPHONATE | — | 1 | 6.28 |
| CHEMBL15848 | ANANDAMIDE | — | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL333149 | ISOPROPYL DODECYLFLUOROPHOSPHONATE | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL97038 | DODECANESULFONYL FLUORIDE | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL112486 | — | IC50 | = | 304.0 | nM | 6.52 |
| CHEMBL113262 | METHOXYARACHIDONOYL FLUOROPHOSPHONATE | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL15848 | ANANDAMIDE | IC50 | = | 12000.0 | nM | 4.92 |