Assay Detail
Binding
CHEMBL658183
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Inhibition of Cyclin-dependent kinase 1-cyclin B from Starfish oocytes
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Asteroidea |
| Cell Type | Oocyte |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 1/cyclin B (CHEMBL2094127) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
2-Substituted paullones: CDK1/cyclin B-inhibiting property and in vitro antiproliferative activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.31 | 7.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL121492 | — | — | 1 | 7.33 |
| CHEMBL419054 | — | — | 1 | 6.57 |
| CHEMBL346406 | — | — | 1 | 6.52 |
| CHEMBL119989 | — | — | 1 | 6.50 |
| CHEMBL296586 | KENPAULLONE | — | 1 | 6.40 |
| CHEMBL329505 | — | — | 1 | 6.40 |
| CHEMBL121957 | — | — | 1 | 6.16 |
| CHEMBL120664 | — | — | 1 | 5.50 |
| CHEMBL121958 | — | — | 1 | 5.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL121492 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL419054 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL346406 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL119989 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL296586 | KENPAULLONE | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL329505 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL121957 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL120664 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL121958 | — | IC50 | = | 4300.0 | nM | 5.37 |