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Assay Detail

CHEMBL658193

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of recombinant Cyclin-dependent kinase 1-cyclin B
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 6 — Multiple protein complex / RNA
Curated By Autocuration

Target

Cyclin-dependent kinase 1/cyclin B (CHEMBL2094127)
Type PROTEIN COMPLEX
Organism Homo sapiens

Publication

Synthesis and biological activity of olomoucine II.
Krystof V, Lenobel R, Havlícek L, Kuzma M, Strnad M.
Bioorg Med Chem Lett (2002) 12 : 3283 -3286
PubMed 12392733 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 6.55 7.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1094304 OLOMOUCINE II 1 7.70
CHEMBL23327 PURVALANOLA 1 7.30
CHEMBL83320 1 7.10
CHEMBL419931 1 7.00
CHEMBL84944 1 6.92
CHEMBL323393 1 6.82
CHEMBL114499 1 6.70
CHEMBL440517 1 6.52
CHEMBL14762 SELICICLIB 2.0 1 6.35
CHEMBL113515 1 6.00
CHEMBL83980 BOHEMINE 1 5.96
CHEMBL111971 1 5.58
CHEMBL280074 OLOMOUCINE 1 5.16

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1094304 OLOMOUCINE II IC50 = 20.0 nM 7.70
CHEMBL23327 PURVALANOLA IC50 = 50.0 nM 7.30
CHEMBL83320 IC50 = 80.0 nM 7.10
CHEMBL419931 IC50 = 100.0 nM 7.00
CHEMBL84944 IC50 = 120.0 nM 6.92
CHEMBL323393 IC50 = 150.0 nM 6.82
CHEMBL114499 IC50 = 200.0 nM 6.70
CHEMBL440517 IC50 = 300.0 nM 6.52
CHEMBL14762 SELICICLIB IC50 = 450.0 nM 6.35
CHEMBL113515 IC50 = 1000.0 nM 6.00
CHEMBL83980 BOHEMINE IC50 = 1100.0 nM 5.96
CHEMBL111971 IC50 = 2600.0 nM 5.58
CHEMBL280074 OLOMOUCINE IC50 = 7000.0 nM 5.16