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Assay Detail

CHEMBL658214

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Binding
Inhibition of bovine membrane bound isozyme carbonic anhydrase IV isolated from microsomes at 20 degree C
ChEMBL ↗
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Carbonic anhydrase 4 (CHEMBL281) ↗
Type SINGLE PROTEIN
Organism Bos taurus

Publication

Carbonic anhydrase inhibitors. Inhibition of mitochondrial isozyme V with aromatic and heterocyclic sulfonamides.
Vullo D, Franchi M, Gallori E, Antel J, Scozzafava A, Supuran CT.
J Med Chem (2004) 47 : 1272 -1279
PubMed 14971907 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 43 6.85 8.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL23435 — — 1 8.40
CHEMBL22540 — — 1 8.40
CHEMBL278603 — — 1 8.40
CHEMBL268439 — — 1 8.30
CHEMBL282021 — — 1 8.10
CHEMBL24473 — — 1 8.10
CHEMBL286004 — — 1 8.00
CHEMBL18 ETHOXZOLAMIDE 4.0 1 7.89
CHEMBL23922 — — 1 7.82
CHEMBL278295 — — 1 7.70
CHEMBL23684 — — 1 7.66
CHEMBL282266 — — 1 7.52
CHEMBL23681 — — 1 7.41
CHEMBL218490 DORZOLAMIDE 4.0 1 7.37
CHEMBL1907940 — — 1 7.35
CHEMBL220492 TOPIRAMATE 4.0 1 7.27
CHEMBL23238 — — 1 7.19
CHEMBL23796 — — 1 7.07
CHEMBL23377 — — 1 6.92
CHEMBL24121 — — 1 6.89
CHEMBL279246 — — 1 6.85
CHEMBL22374 — — 1 6.82
CHEMBL281376 — — 1 6.79
CHEMBL280338 — — 1 6.76
CHEMBL23559 — — 1 6.75
CHEMBL23579 — — 1 6.73
CHEMBL20 ACETAZOLAMIDE 4.0 1 6.66
CHEMBL19 METHAZOLAMIDE 4.0 1 6.62
CHEMBL17 DICHLORPHENAMIDE 4.0 1 6.42
CHEMBL25600 — — 1 6.34

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL23435 — Ki = 4.0 nM 8.40
CHEMBL278603 — Ki = 4.0 nM 8.40
CHEMBL22540 — Ki = 4.0 nM 8.40
CHEMBL268439 — Ki = 5.0 nM 8.30
CHEMBL282021 — Ki = 8.0 nM 8.10
CHEMBL24473 — Ki = 8.0 nM 8.10
CHEMBL286004 — Ki = 10.0 nM 8.00
CHEMBL18 ETHOXZOLAMIDE Ki = 13.0 nM 7.89
CHEMBL23922 — Ki = 15.0 nM 7.82
CHEMBL278295 — Ki = 20.0 nM 7.70
CHEMBL23684 — Ki = 22.0 nM 7.66
CHEMBL282266 — Ki = 30.0 nM 7.52
CHEMBL23681 — Ki = 39.0 nM 7.41
CHEMBL218490 DORZOLAMIDE Ki = 43.0 nM 7.37
CHEMBL1907940 — Ki = 45.0 nM 7.35
CHEMBL220492 TOPIRAMATE Ki = 54.0 nM 7.27
CHEMBL23238 — Ki = 64.0 nM 7.19
CHEMBL23796 — Ki = 85.0 nM 7.07
CHEMBL23377 — Ki = 119.0 nM 6.92
CHEMBL24121 — Ki = 130.0 nM 6.89
CHEMBL279246 — Ki = 140.0 nM 6.85
CHEMBL22374 — Ki = 150.0 nM 6.82
CHEMBL281376 — Ki = 163.0 nM 6.79
CHEMBL280338 — Ki = 174.0 nM 6.76
CHEMBL23559 — Ki = 176.0 nM 6.75
CHEMBL23579 — Ki = 185.0 nM 6.73
CHEMBL20 ACETAZOLAMIDE Ki = 220.0 nM 6.66
CHEMBL19 METHAZOLAMIDE Ki = 240.0 nM 6.62
CHEMBL17 DICHLORPHENAMIDE Ki = 380.0 nM 6.42
CHEMBL25600 — Ki = 460.0 nM 6.34
CHEMBL280417 — Ki = 600.0 nM 6.22
CHEMBL281794 — Ki = 850.0 nM 6.07
CHEMBL23058 — Ki = 980.0 nM 6.01
CHEMBL417648 — Ki = 2100.0 nM 5.68
CHEMBL283097 — Ki = 2370.0 nM 5.62
CHEMBL7087 — Ki = 2500.0 nM 5.60
CHEMBL23591 — Ki = 2540.0 nM 5.59
CHEMBL23285 — Ki = 2550.0 nM 5.59
CHEMBL278395 — Ki = 2630.0 nM 5.58
CHEMBL419 MAFENIDE Ki = 2800.0 nM 5.55
CHEMBL23417 — Ki = 2840.0 nM 5.55
CHEMBL687 ACETYLSULFANILAMIDE Ki = 2850.0 nM 5.54
CHEMBL21 SULFANILAMIDE Ki = 3000.0 nM 5.52