Assay Detail
Binding
CHEMBL658215
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In vitro inhibitory activity against bovine carbonic anhydrase IV (CAIV)
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Carbonic anhydrase inhibitors: synthesis and topical intraocular pressure lowering effects of fluorine-containing inhibitors devoid of enhanced reactivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 35 | 7.07 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 7.89 |
| CHEMBL307939 | — | — | 1 | 7.82 |
| CHEMBL316779 | — | — | 1 | 7.68 |
| CHEMBL319818 | — | — | 1 | 7.68 |
| CHEMBL75855 | — | — | 1 | 7.62 |
| CHEMBL94341 | — | — | 1 | 7.55 |
| CHEMBL74491 | — | — | 1 | 7.51 |
| CHEMBL329956 | — | — | 1 | 7.39 |
| CHEMBL540698 | — | — | 1 | 7.38 |
| CHEMBL309592 | — | — | 1 | 7.38 |
| CHEMBL218490 | DORZOLAMIDE | 4.0 | 1 | 7.37 |
| CHEMBL317890 | — | — | 1 | 7.35 |
| CHEMBL317743 | — | — | 1 | 7.31 |
| CHEMBL76626 | — | — | 1 | 7.31 |
| CHEMBL75620 | — | — | 1 | 7.30 |
| CHEMBL98120 | — | — | 1 | 7.30 |
| CHEMBL306118 | — | — | 1 | 7.27 |
| CHEMBL94499 | — | — | 1 | 7.24 |
| CHEMBL97694 | — | — | 1 | 7.20 |
| CHEMBL77359 | — | — | 1 | 7.20 |
| CHEMBL305726 | — | — | 1 | 7.12 |
| CHEMBL77284 | — | — | 1 | 7.03 |
| CHEMBL308631 | — | — | 1 | 6.92 |
| CHEMBL265534 | — | — | 1 | 6.87 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 6.66 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 6.62 |
| CHEMBL313873 | — | — | 1 | 6.61 |
| CHEMBL97425 | — | — | 1 | 6.48 |
| CHEMBL94746 | — | — | 1 | 6.44 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 6.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL307939 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL316779 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL319818 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL75855 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL94341 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL74491 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL329956 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL540698 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL309592 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL317890 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL317743 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL76626 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL98120 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL75620 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL306118 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL94499 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL77359 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL97694 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL305726 | — | Ki | = | 76.0 | nM | 7.12 |
| CHEMBL77284 | — | Ki | = | 94.0 | nM | 7.03 |
| CHEMBL308631 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL265534 | — | Ki | = | 135.0 | nM | 6.87 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL313873 | — | Ki | = | 245.0 | nM | 6.61 |
| CHEMBL97425 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL94746 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 380.0 | nM | 6.42 |
| CHEMBL76563 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL76956 | — | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL94551 | — | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL97725 | — | Ki | = | 485.0 | nM | 6.31 |
| CHEMBL75747 | — | Ki | = | 690.0 | nM | 6.16 |