Assay Detail
Functional
CHEMBL658301
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Agonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptor
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Enhancement of oral absorption in selective 5-HT1D receptor agonists: fluorinated 3-[3-(piperidin-1-yl)propyl]indoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 8.76 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65367 | — | — | 1 | 10.00 |
| CHEMBL294732 | — | — | 1 | 9.30 |
| CHEMBL294547 | — | — | 1 | 9.22 |
| CHEMBL313714 | — | — | 1 | 8.96 |
| CHEMBL292779 | — | — | 1 | 8.92 |
| CHEMBL304857 | — | — | 1 | 8.80 |
| CHEMBL88893 | — | — | 1 | 8.77 |
| CHEMBL63432 | — | — | 1 | 8.36 |
| CHEMBL63799 | — | — | 1 | 8.29 |
| CHEMBL432332 | — | — | 1 | 7.96 |
| CHEMBL416688 | — | — | 1 | 7.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65367 | — | EC50 | = | 0.1 | nM | 10.00 |
| CHEMBL294732 | — | EC50 | = | 0.5 | nM | 9.30 |
| CHEMBL294547 | — | EC50 | = | 0.6 | nM | 9.22 |
| CHEMBL313714 | — | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL292779 | — | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL304857 | — | EC50 | = | 1.6 | nM | 8.80 |
| CHEMBL88893 | — | EC50 | = | 1.7 | nM | 8.77 |
| CHEMBL63432 | — | EC50 | = | 4.4 | nM | 8.36 |
| CHEMBL63799 | — | EC50 | = | 5.1 | nM | 8.29 |
| CHEMBL432332 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL416688 | — | EC50 | = | 18.0 | nM | 7.75 |