Assay Detail
Functional
CHEMBL658330
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In vitro effective compound concentration required to protect CEM/O cells against the cytopathogenicity of HIV-1
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
The presence of substituents on the aryl moiety of the aryl phosphoramidate derivative of d4T enhances anti-HIV efficacy in cell culture: A structure-activity relationship.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 7.17 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL128665 | — | — | 1 | 8.30 |
| CHEMBL128051 | — | — | 1 | 7.60 |
| CHEMBL128857 | — | — | 1 | 7.40 |
| CHEMBL131285 | — | — | 1 | 7.28 |
| CHEMBL339915 | — | — | 1 | 7.24 |
| CHEMBL128361 | — | — | 1 | 7.12 |
| CHEMBL340928 | — | — | 1 | 7.10 |
| CHEMBL129313 | — | — | 1 | 6.96 |
| CHEMBL338675 | — | — | 1 | 6.89 |
| CHEMBL341137 | — | — | 1 | 6.82 |
| CHEMBL991 | STAVUDINE | 4.0 | 1 | 6.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL128665 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL128051 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL128857 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL131285 | — | EC50 | = | 53.0 | nM | 7.28 |
| CHEMBL339915 | — | EC50 | = | 57.0 | nM | 7.24 |
| CHEMBL128361 | — | EC50 | = | 75.0 | nM | 7.12 |
| CHEMBL340928 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL129313 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL338675 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL341137 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL991 | STAVUDINE | EC50 | = | 651.0 | nM | 6.19 |