Assay Detail
Binding
CHEMBL658336
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Binding affinity against Coagulation factor X in an enzyme inhibition assay.
16
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Preparation of pyrrolidine and isoxazolidine benzamidines as potent inhibitors of coagulation factor Xa.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 7.67 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18767 | — | — | 1 | 8.89 |
| CHEMBL18578 | — | — | 1 | 8.74 |
| CHEMBL279267 | — | — | 1 | 8.51 |
| CHEMBL18225 | — | — | 2 | 8.47 |
| CHEMBL276782 | — | — | 1 | 8.24 |
| CHEMBL279628 | — | — | 1 | 8.20 |
| CHEMBL429068 | — | — | 1 | 7.92 |
| CHEMBL277994 | — | — | 1 | 7.89 |
| CHEMBL275582 | — | — | 1 | 7.58 |
| CHEMBL18627 | — | — | 1 | 7.44 |
| CHEMBL19038 | — | — | 1 | 6.82 |
| CHEMBL19075 | — | — | 1 | 6.77 |
| CHEMBL19090 | — | — | 1 | 6.40 |
| CHEMBL277366 | — | — | 1 | 6.34 |
| CHEMBL435761 | — | — | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18767 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL18578 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL279267 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL18225 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL18225 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL276782 | — | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL279628 | — | Ki | = | 6.3 | nM | 8.20 |
| CHEMBL429068 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL277994 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL275582 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL18627 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL19038 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL19075 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL19090 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL277366 | — | Ki | = | 460.0 | nM | 6.34 |
| CHEMBL435761 | — | Ki | = | 600.0 | nM | 6.22 |