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Assay Detail

CHEMBL658339

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of recombinant human cathepsin S
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Cathepsin S (CHEMBL2954)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

3-Acylamino-azetidin-2-one as a novel class of cysteine proteases inhibitors.
Zhou NE, Guo D, Thomas G, Reddy AV, Kaleta J, Purisima E, Menard R, Micetich RG, Singh R.
Bioorg Med Chem Lett (2003) 13 : 139 -141
PubMed 12467634 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 6.76 7.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL285585 1 7.70
CHEMBL30356 1 7.39
CHEMBL287630 1 7.32
CHEMBL417303 1 6.68
CHEMBL282602 1 6.48
CHEMBL31788 1 6.48
CHEMBL30969 1 6.45
CHEMBL31272 1 5.60
CHEMBL31363 1 -
CHEMBL281518 1 -
CHEMBL284984 1 -
CHEMBL30957 1 -
CHEMBL30401 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL285585 IC50 = 20.0 nM 7.70
CHEMBL30356 IC50 = 41.0 nM 7.39
CHEMBL287630 IC50 = 48.0 nM 7.32
CHEMBL417303 IC50 = 207.0 nM 6.68
CHEMBL282602 IC50 = 330.0 nM 6.48
CHEMBL31788 IC50 = 330.0 nM 6.48
CHEMBL30969 IC50 = 355.0 nM 6.45
CHEMBL31272 IC50 = 2500.0 nM 5.60
CHEMBL31363 IC50 > 2500.0 nM -
CHEMBL281518 IC50 > 5000.0 nM -
CHEMBL284984 IC50 > 2500.0 nM -
CHEMBL30957 IC50 > 2500.0 nM -
CHEMBL30401 IC50 = - nM -